Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate.
Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1991
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| _version_ | 1826283842473820160 |
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| author | Aziz, T Peggs, D Sambrook, M Crossman, A |
| author_facet | Aziz, T Peggs, D Sambrook, M Crossman, A |
| author_sort | Aziz, T |
| collection | OXFORD |
| description | Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder. |
| first_indexed | 2024-03-07T01:04:55Z |
| format | Journal article |
| id | oxford-uuid:8b00e497-efe0-4bff-b67c-88d2c4518237 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:04:55Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:8b00e497-efe0-4bff-b67c-88d2c45182372022-03-26T22:35:17ZLesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8b00e497-efe0-4bff-b67c-88d2c4518237EnglishSymplectic Elements at Oxford1991Aziz, TPeggs, DSambrook, MCrossman, ACentral to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder. |
| spellingShingle | Aziz, T Peggs, D Sambrook, M Crossman, A Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate. |
| title | Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate. |
| title_full | Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate. |
| title_fullStr | Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate. |
| title_full_unstemmed | Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate. |
| title_short | Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate. |
| title_sort | lesion of the subthalamic nucleus for the alleviation of 1 methyl 4 phenyl 1 2 3 6 tetrahydropyridine mptp induced parkinsonism in the primate |
| work_keys_str_mv | AT azizt lesionofthesubthalamicnucleusforthealleviationof1methyl4phenyl1236tetrahydropyridinemptpinducedparkinsonismintheprimate AT peggsd lesionofthesubthalamicnucleusforthealleviationof1methyl4phenyl1236tetrahydropyridinemptpinducedparkinsonismintheprimate AT sambrookm lesionofthesubthalamicnucleusforthealleviationof1methyl4phenyl1236tetrahydropyridinemptpinducedparkinsonismintheprimate AT crossmana lesionofthesubthalamicnucleusforthealleviationof1methyl4phenyl1236tetrahydropyridinemptpinducedparkinsonismintheprimate |