Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.

Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.

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Trans-acting genetic variants have a substantial, albeit poorly characterized, role in the heritable determination of gene expression. Using paired purified primary monocytes and B cells, we identify new predominantly cell type-specific cis and trans expression quantitative trait loci (eQTLs), inclu...

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Bibliografiska uppgifter
Huvudupphovsmän:	Fairfax, B, Makino, S, Radhakrishnan, J, Plant, K, Leslie, S, Dilthey, A, Ellis, P, Langford, C, Vannberg, F, Knight, J
Materialtyp:	Journal article
Språk:	English
Publicerad:	2012

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