Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae
Diphtheria is a respiratory disease caused by the bacterium Corynebacterium diphtheriae. Although the development of a toxin-based vaccine in the 1930s has allowed a high level of control over the disease, cases have increased in recent years. Here, we describe the genomic variation of 502 C. diphth...
| Những tác giả chính: | , , , , , , , , , , , , , , , |
|---|---|
| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
Springer Nature
2021
|
| _version_ | 1826283860184268800 |
|---|---|
| author | Will, RC Ramamurthy, T Sharma, NC Veeraraghavan, B Sangal, L Haldar, P Pragasam, AK Vasudevan, K Kumar, D Das, B Heinz, E Melnikov, V Baker, S Sangal, V Dougan, G Mutreja, A |
| author_facet | Will, RC Ramamurthy, T Sharma, NC Veeraraghavan, B Sangal, L Haldar, P Pragasam, AK Vasudevan, K Kumar, D Das, B Heinz, E Melnikov, V Baker, S Sangal, V Dougan, G Mutreja, A |
| author_sort | Will, RC |
| collection | OXFORD |
| description | Diphtheria is a respiratory disease caused by the bacterium Corynebacterium diphtheriae. Although the development of a toxin-based vaccine in the 1930s has allowed a high level of control over the disease, cases have increased in recent years. Here, we describe the genomic variation of 502 C. diphtheriae isolates across 16 countries and territories over 122 years. We generate a core gene phylogeny and determine the presence of antimicrobial resistance genes and variation within the tox gene of 291 tox+ isolates. Numerous, highly diverse clusters of C. diphtheriae are observed across the phylogeny, each containing isolates from multiple countries, regions and time of isolation. The number of antimicrobial resistance genes, as well as the breadth of antibiotic resistance, is substantially greater in the last decade than ever before. We identified and analysed 18 tox gene variants, with mutations estimated to be of medium to high structural impact. |
| first_indexed | 2024-03-07T01:05:11Z |
| format | Journal article |
| id | oxford-uuid:8b18d5de-ae90-41e1-b2a9-a3c9b11c2fd1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:05:11Z |
| publishDate | 2021 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:8b18d5de-ae90-41e1-b2a9-a3c9b11c2fd12022-03-26T22:35:55ZSpatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriaeJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8b18d5de-ae90-41e1-b2a9-a3c9b11c2fd1EnglishSymplectic ElementsSpringer Nature2021Will, RCRamamurthy, TSharma, NCVeeraraghavan, BSangal, LHaldar, PPragasam, AKVasudevan, KKumar, DDas, BHeinz, EMelnikov, VBaker, SSangal, VDougan, GMutreja, ADiphtheria is a respiratory disease caused by the bacterium Corynebacterium diphtheriae. Although the development of a toxin-based vaccine in the 1930s has allowed a high level of control over the disease, cases have increased in recent years. Here, we describe the genomic variation of 502 C. diphtheriae isolates across 16 countries and territories over 122 years. We generate a core gene phylogeny and determine the presence of antimicrobial resistance genes and variation within the tox gene of 291 tox+ isolates. Numerous, highly diverse clusters of C. diphtheriae are observed across the phylogeny, each containing isolates from multiple countries, regions and time of isolation. The number of antimicrobial resistance genes, as well as the breadth of antibiotic resistance, is substantially greater in the last decade than ever before. We identified and analysed 18 tox gene variants, with mutations estimated to be of medium to high structural impact. |
| spellingShingle | Will, RC Ramamurthy, T Sharma, NC Veeraraghavan, B Sangal, L Haldar, P Pragasam, AK Vasudevan, K Kumar, D Das, B Heinz, E Melnikov, V Baker, S Sangal, V Dougan, G Mutreja, A Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae |
| title | Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae |
| title_full | Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae |
| title_fullStr | Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae |
| title_full_unstemmed | Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae |
| title_short | Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae |
| title_sort | spatiotemporal persistence of multiple diverse clades and toxins of corynebacterium diphtheriae |
| work_keys_str_mv | AT willrc spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae AT ramamurthyt spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae AT sharmanc spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae AT veeraraghavanb spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae AT sangall spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae AT haldarp spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae AT pragasamak spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae AT vasudevank spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae AT kumard spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae AT dasb spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae AT heinze spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae AT melnikovv spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae AT bakers spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae AT sangalv spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae AT dougang spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae AT mutrejaa spatiotemporalpersistenceofmultiplediversecladesandtoxinsofcorynebacteriumdiphtheriae |