Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo.

While memory T cells are maintained by continuous turnover, it is not clear how human regulatory CD4+ CD45RO+ CD25hi Foxp3+ T lymphocyte populations persist throughout life. We therefore used deuterium labeling of cycling cells in vivo to determine whether these cells could be replenished by prolife...

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Bibliographische Detailangaben
Hauptverfasser:	Vukmanovic-Stejic, M, Zhang, Y, Cook, J, Fletcher, J, McQuaid, A, Masters, J, Rustin, M, Taams, L, Beverley, P, Macallan, D, Akbar, A
Format:	Journal article
Sprache:	English
Veröffentlicht:	2006

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo.

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