Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism.

Lignende værker

• Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II).
  af: Jayatunga, M, et al.
  Udgivet: (2015)
• Novel multi-component approaches towards dimeric epidithiodiketopiperazines as anti-cancer agents
  af: Sil, B, et al.
  Udgivet: (2011)
• Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.
  af: Sowter, H, et al.
  Udgivet: (2003)
• Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.
  af: Wood, S, et al.
  Udgivet: (1998)
• Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts.
  af: Mole, D, et al.
  Udgivet: (2009)