Rhomboids, signalling and cell biology
Here, I take a somewhat personal perspective on signalling control, focusing on the rhomboid-like superfamily of proteins that my group has worked on for almost 20 years. As well as describing some of the key and recent advances, I attempt to draw out signalling themes that emerge. One important mes...
| Main Author: | |
|---|---|
| Format: | Journal article |
| Published: |
Portland Press
2016
|
| _version_ | 1826283912750432256 |
|---|---|
| author | Freeman, M |
| author_facet | Freeman, M |
| author_sort | Freeman, M |
| collection | OXFORD |
| description | Here, I take a somewhat personal perspective on signalling control, focusing on the rhomboid-like superfamily of proteins that my group has worked on for almost 20 years. As well as describing some of the key and recent advances, I attempt to draw out signalling themes that emerge. One important message is that the genetic and biochemical perspective on signalling has tended to underplay the importance of cell biology. There is clear evidence that signalling pathways exploit the control of intracellular trafficking, protein quality control and degradation and other cell biological phenomena, as important regulatory opportunities. |
| first_indexed | 2024-03-07T01:05:58Z |
| format | Journal article |
| id | oxford-uuid:8b598540-62a0-44d4-a286-37843807cfb0 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T01:05:58Z |
| publishDate | 2016 |
| publisher | Portland Press |
| record_format | dspace |
| spelling | oxford-uuid:8b598540-62a0-44d4-a286-37843807cfb02022-03-26T22:37:29ZRhomboids, signalling and cell biologyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8b598540-62a0-44d4-a286-37843807cfb0Symplectic Elements at OxfordPortland Press2016Freeman, MHere, I take a somewhat personal perspective on signalling control, focusing on the rhomboid-like superfamily of proteins that my group has worked on for almost 20 years. As well as describing some of the key and recent advances, I attempt to draw out signalling themes that emerge. One important message is that the genetic and biochemical perspective on signalling has tended to underplay the importance of cell biology. There is clear evidence that signalling pathways exploit the control of intracellular trafficking, protein quality control and degradation and other cell biological phenomena, as important regulatory opportunities. |
| spellingShingle | Freeman, M Rhomboids, signalling and cell biology |
| title | Rhomboids, signalling and cell biology |
| title_full | Rhomboids, signalling and cell biology |
| title_fullStr | Rhomboids, signalling and cell biology |
| title_full_unstemmed | Rhomboids, signalling and cell biology |
| title_short | Rhomboids, signalling and cell biology |
| title_sort | rhomboids signalling and cell biology |
| work_keys_str_mv | AT freemanm rhomboidssignallingandcellbiology |