| Summary: | Antagonistic interactions between hosts and pathogens frequently result in arms races. The host attempts to recognise the pathogen and inhibit its growth and spread, whereas the pathogen tries to subvert recognition and suppress host responses. These antagonistic interactions drive the evolution of `decoys' in both hosts and pathogens. In host±pathogen interactions, the term decoy describes molecules that mimic a component at the host±pathogen interface that is manipulated during infection. Decoys undergo the same manipulation as the component they mimic, but they serve the opposite role, either by preventing manipulation of the component they mimic or by triggering a molecular recognition event. At least three different types of decoy have been defined, described in detail below. However, these different decoy models cause confusion on how they function mechanistically. Here, we discuss the three different types of decoys with examples and classify them according to two distinct mechanisms.
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