An interdisciplinary approach to investigate collective cell migration in neural crest
The neural crest serves as a powerful and tractable model paradigm for understanding collective cell migration. The neural crest cell populations are well‐known for their long‐distance collective migration and contribution to diverse cell lineages during vertebrate development. If neural crest cells...
| Hoofdauteurs: | , , , , , |
|---|---|
| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
Wiley
2019
|
| _version_ | 1826284085145763840 |
|---|---|
| author | Giniūnaitė, R McLennan, R McKinney, M Baker, R Kulesa, P Maini, P |
| author_facet | Giniūnaitė, R McLennan, R McKinney, M Baker, R Kulesa, P Maini, P |
| author_sort | Giniūnaitė, R |
| collection | OXFORD |
| description | The neural crest serves as a powerful and tractable model paradigm for understanding collective cell migration. The neural crest cell populations are well‐known for their long‐distance collective migration and contribution to diverse cell lineages during vertebrate development. If neural crest cells fail to reach a target or populate an incorrect location, then improper cell differentiation or uncontrolled cell proliferation can result. A wide range of interdisciplinary studies has been carried out to understand the response of neural crest cells to different stimuli and their ability to migrate to distant targets. In this critical commentary, we illustrate how an interdisciplinary collaboration involving experimental and mathematical modeling has led to a deeper understanding of cranial neural crest cell migration. We identify open questions and propose possible ways to start answering some of the challenges arising.
|
| first_indexed | 2024-03-07T01:08:33Z |
| format | Journal article |
| id | oxford-uuid:8c2f1c0a-29b7-4ff4-afb6-41d4a3e4a086 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:08:33Z |
| publishDate | 2019 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:8c2f1c0a-29b7-4ff4-afb6-41d4a3e4a0862022-03-26T22:43:02ZAn interdisciplinary approach to investigate collective cell migration in neural crestJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8c2f1c0a-29b7-4ff4-afb6-41d4a3e4a086EnglishSymplectic Elements at OxfordWiley2019Giniūnaitė, RMcLennan, RMcKinney, MBaker, RKulesa, PMaini, PThe neural crest serves as a powerful and tractable model paradigm for understanding collective cell migration. The neural crest cell populations are well‐known for their long‐distance collective migration and contribution to diverse cell lineages during vertebrate development. If neural crest cells fail to reach a target or populate an incorrect location, then improper cell differentiation or uncontrolled cell proliferation can result. A wide range of interdisciplinary studies has been carried out to understand the response of neural crest cells to different stimuli and their ability to migrate to distant targets. In this critical commentary, we illustrate how an interdisciplinary collaboration involving experimental and mathematical modeling has led to a deeper understanding of cranial neural crest cell migration. We identify open questions and propose possible ways to start answering some of the challenges arising. |
| spellingShingle | Giniūnaitė, R McLennan, R McKinney, M Baker, R Kulesa, P Maini, P An interdisciplinary approach to investigate collective cell migration in neural crest |
| title | An interdisciplinary approach to investigate collective cell migration in neural crest |
| title_full | An interdisciplinary approach to investigate collective cell migration in neural crest |
| title_fullStr | An interdisciplinary approach to investigate collective cell migration in neural crest |
| title_full_unstemmed | An interdisciplinary approach to investigate collective cell migration in neural crest |
| title_short | An interdisciplinary approach to investigate collective cell migration in neural crest |
| title_sort | interdisciplinary approach to investigate collective cell migration in neural crest |
| work_keys_str_mv | AT giniunaiter aninterdisciplinaryapproachtoinvestigatecollectivecellmigrationinneuralcrest AT mclennanr aninterdisciplinaryapproachtoinvestigatecollectivecellmigrationinneuralcrest AT mckinneym aninterdisciplinaryapproachtoinvestigatecollectivecellmigrationinneuralcrest AT bakerr aninterdisciplinaryapproachtoinvestigatecollectivecellmigrationinneuralcrest AT kulesap aninterdisciplinaryapproachtoinvestigatecollectivecellmigrationinneuralcrest AT mainip aninterdisciplinaryapproachtoinvestigatecollectivecellmigrationinneuralcrest AT giniunaiter interdisciplinaryapproachtoinvestigatecollectivecellmigrationinneuralcrest AT mclennanr interdisciplinaryapproachtoinvestigatecollectivecellmigrationinneuralcrest AT mckinneym interdisciplinaryapproachtoinvestigatecollectivecellmigrationinneuralcrest AT bakerr interdisciplinaryapproachtoinvestigatecollectivecellmigrationinneuralcrest AT kulesap interdisciplinaryapproachtoinvestigatecollectivecellmigrationinneuralcrest AT mainip interdisciplinaryapproachtoinvestigatecollectivecellmigrationinneuralcrest |