Diverse mechanisms of IRF5 action in inflammatory responses
Interferon regulatory factor 5 (IRF5) is a key signal-dependent transcription factor in myeloid cells. Its expression is induced by granulocyte-macrophage colony stimulating factor and interferon-gamma. IRF5 protein is further activated in response to stimulation, translocating to the nucleus where...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Published: |
Elsevier
2018
|
| _version_ | 1797081037157695488 |
|---|---|
| author | Khoyratty, T Udalova, I |
| author_facet | Khoyratty, T Udalova, I |
| author_sort | Khoyratty, T |
| collection | OXFORD |
| description | Interferon regulatory factor 5 (IRF5) is a key signal-dependent transcription factor in myeloid cells. Its expression is induced by granulocyte-macrophage colony stimulating factor and interferon-gamma. IRF5 protein is further activated in response to stimulation, translocating to the nucleus where it mediates inflammatory responses. IRF5 is capable of both the up-regulation of pro-inflammatory genes and repressing anti-inflammatory mediators, thus polarising macrophages to a pro-inflammatory phenotype. We discuss IRF5 interactions with a wide range of transcriptional regulators that give rise to its diverse effects at the level of chromatin. |
| first_indexed | 2024-03-07T01:08:51Z |
| format | Journal article |
| id | oxford-uuid:8c4a051d-7756-4a2f-946e-53eecad6c59b |
| institution | University of Oxford |
| last_indexed | 2024-03-07T01:08:51Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:8c4a051d-7756-4a2f-946e-53eecad6c59b2022-03-26T22:43:37ZDiverse mechanisms of IRF5 action in inflammatory responsesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8c4a051d-7756-4a2f-946e-53eecad6c59bSymplectic Elements at OxfordElsevier2018Khoyratty, TUdalova, IInterferon regulatory factor 5 (IRF5) is a key signal-dependent transcription factor in myeloid cells. Its expression is induced by granulocyte-macrophage colony stimulating factor and interferon-gamma. IRF5 protein is further activated in response to stimulation, translocating to the nucleus where it mediates inflammatory responses. IRF5 is capable of both the up-regulation of pro-inflammatory genes and repressing anti-inflammatory mediators, thus polarising macrophages to a pro-inflammatory phenotype. We discuss IRF5 interactions with a wide range of transcriptional regulators that give rise to its diverse effects at the level of chromatin. |
| spellingShingle | Khoyratty, T Udalova, I Diverse mechanisms of IRF5 action in inflammatory responses |
| title | Diverse mechanisms of IRF5 action in inflammatory responses |
| title_full | Diverse mechanisms of IRF5 action in inflammatory responses |
| title_fullStr | Diverse mechanisms of IRF5 action in inflammatory responses |
| title_full_unstemmed | Diverse mechanisms of IRF5 action in inflammatory responses |
| title_short | Diverse mechanisms of IRF5 action in inflammatory responses |
| title_sort | diverse mechanisms of irf5 action in inflammatory responses |
| work_keys_str_mv | AT khoyrattyt diversemechanismsofirf5actionininflammatoryresponses AT udalovai diversemechanismsofirf5actionininflammatoryresponses |