Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score.
Burning mouth syndrome (BMS) is often an idiopathic chronic and intractable pain condition, affecting 1.5-5.5% of middle-aged and elderly women. We have studied the heat and capsaicin receptor TRPV1, and its regulator nerve growth factor (NGF), in BMS. Patients with BMS (n=10) and controls (n=10) we...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2007
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| _version_ | 1826284108747112448 |
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| author | Yilmaz, Z Renton, T Yiangou, Y Zakrzewska, J Chessell, I Bountra, C Anand, P |
| author_facet | Yilmaz, Z Renton, T Yiangou, Y Zakrzewska, J Chessell, I Bountra, C Anand, P |
| author_sort | Yilmaz, Z |
| collection | OXFORD |
| description | Burning mouth syndrome (BMS) is often an idiopathic chronic and intractable pain condition, affecting 1.5-5.5% of middle-aged and elderly women. We have studied the heat and capsaicin receptor TRPV1, and its regulator nerve growth factor (NGF), in BMS. Patients with BMS (n=10) and controls (n=10) were assessed for baseline and post-topical capsaicin pain scores, and their tongue biopsies immunostained for TRPV1, NGF, and structural nerve markers neurofilament and peripherin. Nerve fibres penetrating the epithelium were less abundant in BMS (p<0.0001), indicating a small fibre neuropathy. TRPV1-positive fibres were overall significantly increased in BMS (p=0.0011), as were NGF fibres (p<0.0001) and basal epithelial cell NGF staining (p<0.0147). There was a significant correlation between the baseline pain score and TRPV1 (p=0.0143) and NGF fibres (p=0.0252). A significant correlation was observed between baseline and post-capsaicin pain (p=0.0006). Selective TRPV1 and NGF blockers may provide a new therapy for BMS. |
| first_indexed | 2024-03-07T01:08:55Z |
| format | Journal article |
| id | oxford-uuid:8c4f8740-605c-4fb2-976b-c788a8df855d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:08:55Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:8c4f8740-605c-4fb2-976b-c788a8df855d2022-03-26T22:43:44ZBurning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8c4f8740-605c-4fb2-976b-c788a8df855dEnglishSymplectic Elements at Oxford2007Yilmaz, ZRenton, TYiangou, YZakrzewska, JChessell, IBountra, CAnand, PBurning mouth syndrome (BMS) is often an idiopathic chronic and intractable pain condition, affecting 1.5-5.5% of middle-aged and elderly women. We have studied the heat and capsaicin receptor TRPV1, and its regulator nerve growth factor (NGF), in BMS. Patients with BMS (n=10) and controls (n=10) were assessed for baseline and post-topical capsaicin pain scores, and their tongue biopsies immunostained for TRPV1, NGF, and structural nerve markers neurofilament and peripherin. Nerve fibres penetrating the epithelium were less abundant in BMS (p<0.0001), indicating a small fibre neuropathy. TRPV1-positive fibres were overall significantly increased in BMS (p=0.0011), as were NGF fibres (p<0.0001) and basal epithelial cell NGF staining (p<0.0147). There was a significant correlation between the baseline pain score and TRPV1 (p=0.0143) and NGF fibres (p=0.0252). A significant correlation was observed between baseline and post-capsaicin pain (p=0.0006). Selective TRPV1 and NGF blockers may provide a new therapy for BMS. |
| spellingShingle | Yilmaz, Z Renton, T Yiangou, Y Zakrzewska, J Chessell, I Bountra, C Anand, P Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. |
| title | Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. |
| title_full | Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. |
| title_fullStr | Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. |
| title_full_unstemmed | Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. |
| title_short | Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. |
| title_sort | burning mouth syndrome as a trigeminal small fibre neuropathy increased heat and capsaicin receptor trpv1 in nerve fibres correlates with pain score |
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