Heterogeneity of B cells reacting with T-cell factors. Evidence for matching T-cell and B-cell subsets.
Spleen T cells have been stimulated with Concanavalin A (Con A) under conditions which lead to the production of non-specific factor (NSF), a substance which replaces T cells for B-cell responses to certain antigens. We have examined the ability of multiple aliquots of B cells to react to the NSF de...
| Главные авторы: | , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
1977
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| _version_ | 1826284111149400064 |
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| author | Lefkovits, I Waldmann, H |
| author_facet | Lefkovits, I Waldmann, H |
| author_sort | Lefkovits, I |
| collection | OXFORD |
| description | Spleen T cells have been stimulated with Concanavalin A (Con A) under conditions which lead to the production of non-specific factor (NSF), a substance which replaces T cells for B-cell responses to certain antigens. We have examined the ability of multiple aliquots of B cells to react to the NSF derived from single T cells, and have found great heterogeneity of response. We postulate that there exist subsets of T cells which vary in either the quantity or the quality of the non-specific factor(s) they can produce on stimulation, and that in turn there must also be matching subsets of B cells which may vary in their susceptibility to such factors. |
| first_indexed | 2024-03-07T01:08:57Z |
| format | Journal article |
| id | oxford-uuid:8c51a7e1-5c8f-417c-bee8-c5127ffdff1f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:08:57Z |
| publishDate | 1977 |
| record_format | dspace |
| spelling | oxford-uuid:8c51a7e1-5c8f-417c-bee8-c5127ffdff1f2022-03-26T22:43:48ZHeterogeneity of B cells reacting with T-cell factors. Evidence for matching T-cell and B-cell subsets.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8c51a7e1-5c8f-417c-bee8-c5127ffdff1fEnglishSymplectic Elements at Oxford1977Lefkovits, IWaldmann, HSpleen T cells have been stimulated with Concanavalin A (Con A) under conditions which lead to the production of non-specific factor (NSF), a substance which replaces T cells for B-cell responses to certain antigens. We have examined the ability of multiple aliquots of B cells to react to the NSF derived from single T cells, and have found great heterogeneity of response. We postulate that there exist subsets of T cells which vary in either the quantity or the quality of the non-specific factor(s) they can produce on stimulation, and that in turn there must also be matching subsets of B cells which may vary in their susceptibility to such factors. |
| spellingShingle | Lefkovits, I Waldmann, H Heterogeneity of B cells reacting with T-cell factors. Evidence for matching T-cell and B-cell subsets. |
| title | Heterogeneity of B cells reacting with T-cell factors. Evidence for matching T-cell and B-cell subsets. |
| title_full | Heterogeneity of B cells reacting with T-cell factors. Evidence for matching T-cell and B-cell subsets. |
| title_fullStr | Heterogeneity of B cells reacting with T-cell factors. Evidence for matching T-cell and B-cell subsets. |
| title_full_unstemmed | Heterogeneity of B cells reacting with T-cell factors. Evidence for matching T-cell and B-cell subsets. |
| title_short | Heterogeneity of B cells reacting with T-cell factors. Evidence for matching T-cell and B-cell subsets. |
| title_sort | heterogeneity of b cells reacting with t cell factors evidence for matching t cell and b cell subsets |
| work_keys_str_mv | AT lefkovitsi heterogeneityofbcellsreactingwithtcellfactorsevidenceformatchingtcellandbcellsubsets AT waldmannh heterogeneityofbcellsreactingwithtcellfactorsevidenceformatchingtcellandbcellsubsets |