Interplay between influenza virus and the host RNA polymerase II transcriptional machinery
The influenza virus RNA-dependent RNA polymerase (RdRP) cleaves the 5′ end of nascent capped host RNAs and uses the capped RNA fragment to prime viral transcription in a mechanism called ‘cap snatching’. Cap snatching requires an intimate association between influenza RdRP and cellular RNA polymeras...
| Main Authors: | , |
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| פורמט: | Journal article |
| יצא לאור: |
Cell Press
2019
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| _version_ | 1826284113323098112 |
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| author | Walker, A Fodor, E |
| author_facet | Walker, A Fodor, E |
| author_sort | Walker, A |
| collection | OXFORD |
| description | The influenza virus RNA-dependent RNA polymerase (RdRP) cleaves the 5′ end of nascent capped host RNAs and uses the capped RNA fragment to prime viral transcription in a mechanism called ‘cap snatching’. Cap snatching requires an intimate association between influenza RdRP and cellular RNA polymerase II (Pol II), which is the source of nascent capped host RNAs targeted by influenza virus. Recent structural studies have revealed how influenza RdRP binds to Pol II and how this binding promotes the initiation of viral transcription by influenza RdRP. In this review we focus on these recent insights into the mechanism of cap snatching by influenza virus and the impact of cap snatching on host gene expression during influenza virus infection. |
| first_indexed | 2024-03-07T01:08:59Z |
| format | Journal article |
| id | oxford-uuid:8c53a037-df6f-4e16-b28e-62b38466dafb |
| institution | University of Oxford |
| last_indexed | 2024-03-07T01:08:59Z |
| publishDate | 2019 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:8c53a037-df6f-4e16-b28e-62b38466dafb2022-03-26T22:43:56ZInterplay between influenza virus and the host RNA polymerase II transcriptional machineryJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8c53a037-df6f-4e16-b28e-62b38466dafbSymplectic Elements at OxfordCell Press2019Walker, AFodor, EThe influenza virus RNA-dependent RNA polymerase (RdRP) cleaves the 5′ end of nascent capped host RNAs and uses the capped RNA fragment to prime viral transcription in a mechanism called ‘cap snatching’. Cap snatching requires an intimate association between influenza RdRP and cellular RNA polymerase II (Pol II), which is the source of nascent capped host RNAs targeted by influenza virus. Recent structural studies have revealed how influenza RdRP binds to Pol II and how this binding promotes the initiation of viral transcription by influenza RdRP. In this review we focus on these recent insights into the mechanism of cap snatching by influenza virus and the impact of cap snatching on host gene expression during influenza virus infection. |
| spellingShingle | Walker, A Fodor, E Interplay between influenza virus and the host RNA polymerase II transcriptional machinery |
| title | Interplay between influenza virus and the host RNA polymerase II transcriptional machinery |
| title_full | Interplay between influenza virus and the host RNA polymerase II transcriptional machinery |
| title_fullStr | Interplay between influenza virus and the host RNA polymerase II transcriptional machinery |
| title_full_unstemmed | Interplay between influenza virus and the host RNA polymerase II transcriptional machinery |
| title_short | Interplay between influenza virus and the host RNA polymerase II transcriptional machinery |
| title_sort | interplay between influenza virus and the host rna polymerase ii transcriptional machinery |
| work_keys_str_mv | AT walkera interplaybetweeninfluenzavirusandthehostrnapolymeraseiitranscriptionalmachinery AT fodore interplaybetweeninfluenzavirusandthehostrnapolymeraseiitranscriptionalmachinery |