A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRDM9-bound loci do not become recombination hotspots. To explore factors that affect binding and subsequent recombination outcomes, we mapped human PRDM9 binding sites in a transfected human cell line a...
Main Authors: | Altemose, N, Noor, N, Bitoun, E, Tumian, A, Imbeault, M, Chapman, J, Aricescu, A, Myers, S |
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Format: | Journal article |
Published: |
eLife Sciences
2017
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