The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase.

Recent studies have demonstrated that histone methylation can be dynamically regulated through active demethylation. However, no demethylase specific to histone H3 trimethyl-Lys4 (H3K4me3) has been identified. Here we report that the Drosophila melanogaster protein 'little imaginal discs'...

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Bibliographic Details
Main Authors: Lee, N, Zhang, J, Klose, R, Erdjument-Bromage, H, Tempst, P, Jones, R, Zhang, Y
Format: Journal article
Language:English
Published: 2007
Description
Summary:Recent studies have demonstrated that histone methylation can be dynamically regulated through active demethylation. However, no demethylase specific to histone H3 trimethyl-Lys4 (H3K4me3) has been identified. Here we report that the Drosophila melanogaster protein 'little imaginal discs' (Lid), a JmjC domain-containing trithorax group protein, can demethylate H3K4me3. Consistent with its genetic classification, Lid positively regulates Hox gene expression in S2 cells.