Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections.
We studied infection dynamics of Plasmodium chabaudi in mice infected with 3 genetically distinct clones--1 less virulent than the other 2--either on their own or in mixtures. During the acute phase of infection, total numbers of asexual parasites in mixed-clone infections were equal to those produc...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2003
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| _version_ | 1797081078983294976 |
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| author | De Roode, J Read, A Chan, B Mackinnon, M |
| author_facet | De Roode, J Read, A Chan, B Mackinnon, M |
| author_sort | De Roode, J |
| collection | OXFORD |
| description | We studied infection dynamics of Plasmodium chabaudi in mice infected with 3 genetically distinct clones--1 less virulent than the other 2--either on their own or in mixtures. During the acute phase of infection, total numbers of asexual parasites in mixed-clone infections were equal to those produced by the 3 clones alone, suggesting strong in-host competition among clones. During the chronic phase of the infection, mixed-clone infections produced more asexual parasites than single-clone infections, suggesting lower levels of competition than during the acute phase, and indicating that a genetically diverse infection is harder to control by the host immune system. Transmission potential over the whole course of infection was lower from mixed-clone infections than from the average of the 3 single-clone infections. These results suggest that in-host competition reduces both growth rate and probability of transmission for individual parasite clones. |
| first_indexed | 2024-03-07T01:09:26Z |
| format | Journal article |
| id | oxford-uuid:8c7e5dc8-0338-4fd8-991b-2eeee8039bb3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:09:26Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:8c7e5dc8-0338-4fd8-991b-2eeee8039bb32022-03-26T22:44:53ZRodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8c7e5dc8-0338-4fd8-991b-2eeee8039bb3EnglishSymplectic Elements at Oxford2003De Roode, JRead, AChan, BMackinnon, MWe studied infection dynamics of Plasmodium chabaudi in mice infected with 3 genetically distinct clones--1 less virulent than the other 2--either on their own or in mixtures. During the acute phase of infection, total numbers of asexual parasites in mixed-clone infections were equal to those produced by the 3 clones alone, suggesting strong in-host competition among clones. During the chronic phase of the infection, mixed-clone infections produced more asexual parasites than single-clone infections, suggesting lower levels of competition than during the acute phase, and indicating that a genetically diverse infection is harder to control by the host immune system. Transmission potential over the whole course of infection was lower from mixed-clone infections than from the average of the 3 single-clone infections. These results suggest that in-host competition reduces both growth rate and probability of transmission for individual parasite clones. |
| spellingShingle | De Roode, J Read, A Chan, B Mackinnon, M Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections. |
| title | Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections. |
| title_full | Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections. |
| title_fullStr | Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections. |
| title_full_unstemmed | Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections. |
| title_short | Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections. |
| title_sort | rodent malaria parasites suffer from the presence of conspecific clones in three clone plasmodium chabaudi infections |
| work_keys_str_mv | AT deroodej rodentmalariaparasitessufferfromthepresenceofconspecificclonesinthreecloneplasmodiumchabaudiinfections AT reada rodentmalariaparasitessufferfromthepresenceofconspecificclonesinthreecloneplasmodiumchabaudiinfections AT chanb rodentmalariaparasitessufferfromthepresenceofconspecificclonesinthreecloneplasmodiumchabaudiinfections AT mackinnonm rodentmalariaparasitessufferfromthepresenceofconspecificclonesinthreecloneplasmodiumchabaudiinfections |