Adenovirus VA RNAI blocks ASC oligomerization and inhibits NLRP3 inflammasome activation

Adenovirus VA RNAI blocks ASC oligomerization and inhibits NLRP3 inflammasome activation

Virus infected immune cells can rapidly respond to the invader by activating the inflammasome and as a consequence release proinflammatory cytokines and eventually die by pyroptosis. In human adenovirus-5 (Ad5) infected THP-1 cells, inhibition of NLRP3 inflammasome activation was demonstrated by a d...

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Bibliographic Details
Main Authors:	Darweesh, M, Kamel, W, Gavrilin, MA, Akusjärvi, G, Svensson, C
Format:	Journal article
Published:	Frontiers Media 2019

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