A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program

Although 90% of children with acute lymphoblastic leukemia (ALL) are now cured, the prognosis for infant-ALL remains dismal. Infant-ALL is usually caused by a single genetic hit that arises in utero: an MLL/KMT2A gene rearrangement (MLL-r). This is sufficient to induce a uniquely aggressive and trea...

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Үндсэн зохиолчид: Rice, S, Jackson, T, Crump, NT, Fordham, N, Elliott, N, O’Byrne, S, Fanego, MDML, Addy, D, Crabb, T, Dryden, C, Inglott, S, Ladon, D, Wright, G, Bartram, J, Ancliff, P, Mead, AJ, Halsey, C, Roberts, I, Milne, TA, Roy, A
Формат: Journal article
Хэл сонгох:English
Хэвлэсэн: Springer Nature 2021

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