Extensive genetic diversity in the HLA class II region of Africans, with a focally predominant allele, DRB1*1304.
Molecular HLA class II typing of greater than 1700 individuals from The Gambia in West Africa and Malawi in South-Central Africa revealed a striking diversity of HLA DRB-DQB haplotypes as defined by restriction fragment length polymorphism (RFLP); this diversity is twice as extensive as that found i...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1992
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| _version_ | 1797081129225814016 |
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| author | Hill, A Allsopp, C Kwiatkowski, D Taylor, T Yates, SN Anstey, N Wirima, J Brewster, DR Mcmichael, A Molyneux, M |
| author_facet | Hill, A Allsopp, C Kwiatkowski, D Taylor, T Yates, SN Anstey, N Wirima, J Brewster, DR Mcmichael, A Molyneux, M |
| author_sort | Hill, A |
| collection | OXFORD |
| description | Molecular HLA class II typing of greater than 1700 individuals from The Gambia in West Africa and Malawi in South-Central Africa revealed a striking diversity of HLA DRB-DQB haplotypes as defined by restriction fragment length polymorphism (RFLP); this diversity is twice as extensive as that found in northern Europeans. Despite this diversity, sequence and PCR/oligonucleotide analysis showed that the recently described variant DRB1*1304 is the commonest DRB1 allele in The Gambia. The sequence, geographical distribution, and RFLP association of this allele, together with homozygosity test results, suggest that DRB1*1304 may have arisen from DRB1*1102 and have reached its remarkably high frequency as a result of recent directional selection. The prevalence of this unusual allele has implications for trials of subunit vaccines in this area. The extensive and distinctive HLA class II region polymorphism in sub-Saharan Africans is consistent with evidence from other genetic loci implying an African origin of modern Homo sapiens. |
| first_indexed | 2024-03-07T01:10:09Z |
| format | Journal article |
| id | oxford-uuid:8cb5f050-1f79-4bd9-868d-b5ffe1f753fe |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:10:09Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:8cb5f050-1f79-4bd9-868d-b5ffe1f753fe2022-03-26T22:46:22ZExtensive genetic diversity in the HLA class II region of Africans, with a focally predominant allele, DRB1*1304.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8cb5f050-1f79-4bd9-868d-b5ffe1f753feEnglishSymplectic Elements at Oxford1992Hill, AAllsopp, CKwiatkowski, DTaylor, TYates, SNAnstey, NWirima, JBrewster, DRMcmichael, AMolyneux, MMolecular HLA class II typing of greater than 1700 individuals from The Gambia in West Africa and Malawi in South-Central Africa revealed a striking diversity of HLA DRB-DQB haplotypes as defined by restriction fragment length polymorphism (RFLP); this diversity is twice as extensive as that found in northern Europeans. Despite this diversity, sequence and PCR/oligonucleotide analysis showed that the recently described variant DRB1*1304 is the commonest DRB1 allele in The Gambia. The sequence, geographical distribution, and RFLP association of this allele, together with homozygosity test results, suggest that DRB1*1304 may have arisen from DRB1*1102 and have reached its remarkably high frequency as a result of recent directional selection. The prevalence of this unusual allele has implications for trials of subunit vaccines in this area. The extensive and distinctive HLA class II region polymorphism in sub-Saharan Africans is consistent with evidence from other genetic loci implying an African origin of modern Homo sapiens. |
| spellingShingle | Hill, A Allsopp, C Kwiatkowski, D Taylor, T Yates, SN Anstey, N Wirima, J Brewster, DR Mcmichael, A Molyneux, M Extensive genetic diversity in the HLA class II region of Africans, with a focally predominant allele, DRB1*1304. |
| title | Extensive genetic diversity in the HLA class II region of Africans, with a focally predominant allele, DRB1*1304. |
| title_full | Extensive genetic diversity in the HLA class II region of Africans, with a focally predominant allele, DRB1*1304. |
| title_fullStr | Extensive genetic diversity in the HLA class II region of Africans, with a focally predominant allele, DRB1*1304. |
| title_full_unstemmed | Extensive genetic diversity in the HLA class II region of Africans, with a focally predominant allele, DRB1*1304. |
| title_short | Extensive genetic diversity in the HLA class II region of Africans, with a focally predominant allele, DRB1*1304. |
| title_sort | extensive genetic diversity in the hla class ii region of africans with a focally predominant allele drb1 1304 |
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