Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis.
BACKGROUND: The nature of the association between severe respiratory syncytial virus (RSV) bronchiolitis and subsequent wheezing remains unknown. In a previous study, we showed that genetic variation in the IL-8-promoter region is associated with susceptibility to severe bronchiolitis. OBJECTIVE: Th...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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| _version_ | 1797081135287631872 |
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| author | Goetghebuer, T Isles, K Moore, C Thomson, A Kwiatkowski, D Hull, J |
| author_facet | Goetghebuer, T Isles, K Moore, C Thomson, A Kwiatkowski, D Hull, J |
| author_sort | Goetghebuer, T |
| collection | OXFORD |
| description | BACKGROUND: The nature of the association between severe respiratory syncytial virus (RSV) bronchiolitis and subsequent wheezing remains unknown. In a previous study, we showed that genetic variation in the IL-8-promoter region is associated with susceptibility to severe bronchiolitis. OBJECTIVE: The purpose of this study was to assess the association between wheezing post-bronchiolitis and the genetic variant of IL-8 gene. METHODS: We collected data from 134 children who had suffered from bronchiolitis, enrolled in our previous study. The occurrence of wheezing post-bronchiolitis was recorded from a questionnaire sent by post. The association between the genotype and wheezing phenotype was assessed by family-based and case-control approaches. RESULTS: Family-based association showed that the IL-8 variant was transmitted significantly more often than expected in the children who wheezed after the episode of bronchiolitis (transmission=56%, P=0.02). This effect was not observed in the group of children who had bronchiolitis but did not go on to wheeze. Moreover, the variant was significantly more frequent in post-bronchiolitis wheezers compared with the general population (odds ratio=1.6, 95% confidence interval 1.0-2.6). CONCLUSION: These preliminary results suggest that there is a genetic predisposition to wheeze following severe RSV bronchiolitis. |
| first_indexed | 2024-03-07T01:10:14Z |
| format | Journal article |
| id | oxford-uuid:8cbed239-5664-4192-b9b9-24751a817867 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:10:14Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:8cbed239-5664-4192-b9b9-24751a8178672022-03-26T22:46:32ZGenetic predisposition to wheeze following respiratory syncytial virus bronchiolitis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8cbed239-5664-4192-b9b9-24751a817867EnglishSymplectic Elements at Oxford2004Goetghebuer, TIsles, KMoore, CThomson, AKwiatkowski, DHull, JBACKGROUND: The nature of the association between severe respiratory syncytial virus (RSV) bronchiolitis and subsequent wheezing remains unknown. In a previous study, we showed that genetic variation in the IL-8-promoter region is associated with susceptibility to severe bronchiolitis. OBJECTIVE: The purpose of this study was to assess the association between wheezing post-bronchiolitis and the genetic variant of IL-8 gene. METHODS: We collected data from 134 children who had suffered from bronchiolitis, enrolled in our previous study. The occurrence of wheezing post-bronchiolitis was recorded from a questionnaire sent by post. The association between the genotype and wheezing phenotype was assessed by family-based and case-control approaches. RESULTS: Family-based association showed that the IL-8 variant was transmitted significantly more often than expected in the children who wheezed after the episode of bronchiolitis (transmission=56%, P=0.02). This effect was not observed in the group of children who had bronchiolitis but did not go on to wheeze. Moreover, the variant was significantly more frequent in post-bronchiolitis wheezers compared with the general population (odds ratio=1.6, 95% confidence interval 1.0-2.6). CONCLUSION: These preliminary results suggest that there is a genetic predisposition to wheeze following severe RSV bronchiolitis. |
| spellingShingle | Goetghebuer, T Isles, K Moore, C Thomson, A Kwiatkowski, D Hull, J Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis. |
| title | Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis. |
| title_full | Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis. |
| title_fullStr | Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis. |
| title_full_unstemmed | Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis. |
| title_short | Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis. |
| title_sort | genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis |
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