Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells.
It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling. Here, we set out to test the importance of receptor-ligand complex dimensions for immune surveillance of target cells by human N...
Main Authors: | Köhler, K, Xiong, S, Brzostek, J, Mehrabi, M, Eissmann, P, Harrison, A, Cordoba, S, Oddos, S, Miloserdov, V, Gould, K, Burroughs, N, van der Merwe, P, Davis, D |
---|---|
Formato: | Journal article |
Idioma: | English |
Publicado em: |
Public Library of Science
2010
|
Registos relacionados
-
Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells.
Por: Karsten Köhler, et al.
Publicado em: (2010-11-01) -
The importance of ligand dimensions in natural killer cell inhibition
Por: Brzostek, J, et al.
Publicado em: (2008) -
Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses
Por: Burroughs, N, et al.
Publicado em: (2011) -
Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy
Por: Brown, A, et al.
Publicado em: (2011) -
Key Activating and Inhibitory Ligands Involved in the Mobilization of Natural Killer Cells for Cancer Immunotherapies
Por: Karmakar S, et al.
Publicado em: (2021-11-01)