Phase 1 evaluation of 3 highly immunogenic prime-boost regimens, including a 12-month reboosting vaccination, for malaria vaccination in Gambian men.

Phase 1 evaluation of 3 highly immunogenic prime-boost regimens, including a 12-month reboosting vaccination, for malaria vaccination in Gambian men.

Successful vaccination against intracellular pathogens, including liver-stage Plasmodium falciparum, will require induction of strong antigen-specific T lymphocyte responses. The multiple epitope (ME)-thrombospondin-related adhesion protein (TRAP) construct includes CD8(+) and CD4(+) T cell epitopes...

Full description

Bibliographic Details
Main Authors:	Moorthy, V, Imoukhuede, E, Keating, S, Pinder, M, Webster, D, Skinner, M, Gilbert, S, Walraven, G, Hill, A
Format:	Conference item
Published:	2004

Similar Items

Differential immunogenicity of various heterologous prime-boost vaccine regimens using DNA and viral vectors in healthy volunteers.
by: Vuola, J, et al.
Published: (2005)

A randomised, double-blind, controlled vaccine efficacy trial of DNA/MVA ME-TRAP against malaria infection in Gambian adults.
by: Moorthy, V, et al.
Published: (2004)

Safety and immunogenicity of the malaria candidate vaccines FP9 CS and MVA CS in adult Gambian men.
by: Imoukhuede, E, et al.
Published: (2006)

Safety and immunogenicity of a heterologous prime-boost Ebola virus vaccine regimen in healthy adults in the United Kingdom and Senegal
by: Venkatraman, N, et al.
Published: (2018)

Synergistic DNA-MVA prime-boost vaccination regimes for malaria and tuberculosis.
by: Gilbert, S, et al.
Published: (2006)

Safety and immunogenicity of heterologous prime-boost immunisation with Plasmodium falciparum malaria candidate vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, in healthy Gambian and Kenyan adults.
by: Ogwang, C, et al.
Published: (2013)

Safety and immunogenicity of malaria vectored vaccines given with routine EPI vaccines in Gambian infants and neonates: a randomized controlled trial
by: Mensah, V, et al.
Published: (2017)

Influence of genetic and environmental factors on the immunogenicity of Hib vaccine in Gambian twins.
by: Lee, Y, et al.
Published: (2006)

Influence of genetic and environmental factors on the immunogenicity of Hib vaccine in Gambian twins
by: Lee, Y, et al.
Published: (2006)

Reactogenicity and immunogenicity of heterologous prime-boost immunization with COVID-19 vaccine
by: Thuy Trang Nguyen, et al.
Published: (2022-03-01)

Construction and immunogenicity in a prime-boost regimen of a Semliki Forest virus-vectored experimental HIV clade A vaccine.
by: Hanke, T, et al.
Published: (2003)

Enhanced immunogenicity of CD4(+) t-cell responses and protective efficacy of a DNA-modified vaccinia virus Ankara prime-boost vaccination regimen for murine tuberculosis.
by: Mcshane, H, et al.
Published: (2001)

Conserved immunogens in prime-boost strategies for the next-generation HIV-1 vaccines.
by: Hanke, T
Published: (2014)

Short or Long Interval between Priming and Boosting: Does It Impact on the Vaccine Immunogenicity?
by: Elena Pettini, et al.
Published: (2021-03-01)

Safety and immunogenicity of the heterologous prime-boost ebolavirus vaccine regimen CHAD3-EBO Z and MVA-BN (R) FILO in healthy UK adults
by: Rampling, T, et al.
Published: (2015)

Immunogenicity and persistence of a prime-boost re-vaccination strategy for pneumococcal vaccines in patients with rheumatoid arthritis
by: Mathilde Bahuaud, et al.
Published: (2018-06-01)

Different levels of immunogenicity of two strains of Fowlpox virus as recombinant vaccine vectors eliciting T-cell responses in heterologous prime-boost vaccination strategies.
by: Cottingham, MG, et al.
Published: (2006)

Safety and Immunogenicity of Malaria Vectored Vaccines Given with Routine Expanded Program on Immunization Vaccines in Gambian Infants and Neonates: A Randomized Controlled Trial
by: Victorine A. Mensah, et al.
Published: (2017-11-01)

Immunogenicity of Low-Dose Prime-Boost Vaccination of mRNA Vaccine CV07050101 in Non-Human Primates
by: Neeltje van Doremalen, et al.
Published: (2021-08-01)

Immunogenicity study of dna vaccine and dna vaccine carrier expressing vp1 of enterovirus 71 in the prime boost vaccination strategy
by: Nur Ayuni, Kadir
Published: (2008)

Immunogenicity of the Tuberculosis Vaccine MVA85A Is Reduced by Coadministration with EPI Vaccines in a Randomized Controlled Trial in Gambian Infants
by: Ota, M, et al.
Published: (2011)

Immunogenicity of the tuberculosis vaccine MVA85A is reduced by coadministration with EPI vaccines in a randomized controlled trial in Gambian infants.
by: Ota, M, et al.
Published: (2011)

Comparison of the immunogenicity and protection against bovine tuberculosis following immunization by BCG-priming and boosting with adenovirus or protein based vaccines.
by: Dean, G, et al.
Published: (2014)

Prime-boost vectored malaria vaccines: progress and prospects.
by: Hill, A, et al.
Published: (2010)

Safety and immunogenicity of heterologous prime-boost immunization with viral-vectored malaria vaccines adjuvanted with Matrix-M
by: Venkatraman, N, et al.
Published: (2017)

Investigation of the Optimal Prime Boost Spacing Regimen for a Cancer Therapeutic Vaccine Targeting Human Papillomavirus
by: Diane M. Da Silva, et al.
Published: (2022-09-01)

DNA-based vaccines for malaria: a heterologous prime-boost immunisation strategy.
by: Hill, A, et al.
Published: (2000)

Immunological impact of an additional early measles vaccine in Gambian children: Responses to a boost at 3 years
by: Njie-Jobe, J, et al.
Published: (2012)

Immunological impact of an additional early measles vaccine in Gambian children: responses to a boost at 3 years.
by: Njie-Jobe, J, et al.
Published: (2012)

Heterologous Prime-Boost Vaccination with Commercial FMD Vaccines Elicits a Broader Immune Response than Homologous Prime-Boost Vaccination in Pigs
by: Jaejo Kim, et al.
Published: (2023-02-01)

Immunogenicity and protective efficacy of prime-boost immunization in mice vaccinated with live and inactivated influenza A (H5N1) vaccines
by: I. Losev, et al.
Published: (2019-05-01)

Exploring Prime-Boost Vaccination Regimens with Different H1N1 Swine Influenza A Virus Strains and Vaccine Platforms
by: Anna Parys, et al.
Published: (2022-10-01)

Prime-boost strategies for malaria vaccine development.
by: Dunachie, S, et al.
Published: (2003)

Immunogenicity and Safety of Homologous and Heterologous Prime–Boost Immunization with COVID-19 Vaccine: Systematic Review and Meta-Analysis
by: Haoyue Cheng, et al.
Published: (2022-05-01)

Immunogenicity and reactogenicity after heterologous prime-boost vaccination with CoronaVac and ChAdox1 nCov-19 (AZD1222) vaccines
by: Guy Cohen, et al.
Published: (2022-11-01)

Safety, Immunogenicity and Efficacy of Prime-Boost Vaccination with ChAd63 and MVA Encoding ME-TRAP against Plasmodium falciparum Infection in Adults in Senegal.
by: Mensah, V, et al.
Published: (2016)

Ovine atadenovirus, a novel and highly immunogenic vector in prime-boost studies of a candidate HIV-1 vaccine.
by: Bridgeman, A, et al.
Published: (2009)

Evaluating the sensitivity of the bovine BCG challenge model using a prime boost Ad85A vaccine regimen
by: Biffar, L, et al.
Published: (2019)

Prime-Boost Vaccine Regimen for SjTPI and SjC23 Schistosome Vaccines, Increases Efficacy in Water Buffalo in a Field Trial in China
by: Akram A. Da'Dara, et al.
Published: (2019-02-01)

Safety and immunogenicity of DNA/modified vaccinia virus ankara malaria vaccination in African adults.
by: Moorthy, V, et al.
Published: (2003)