Structure–function relationships of human JmjC oxygenases — demethylases versus hydroxylases

Structure–function relationships of human JmjC oxygenases — demethylases versus hydroxylases

The Jumonji-C (JmjC) subfamily of 2-oxoglutarate (2OG)-dependent oxygenases are of biomedical interest because of their roles in the regulation of gene expression and protein biosynthesis. Human JmjC 2OG oxygenases catalyze oxidative modifications to give either chemically stable alcohol products, o...

Full description

Bibliographic Details
Main Authors:	Markolovic, S, Leissing, T, Chowdhury, R, Wilkins, S, Lu, X, Schofield, C
Format:	Journal article
Language:	English
Published:	Elsevier 2016

Similar Items

Inhibitors of both the N-methyl lysyl- and arginyl- demethylase activities of the JmjC oxygenases
by: Bonnici, J, et al.
Published: (2018)

Is JmjC oxygenase catalysis limited to demethylation?
by: Hopkinson, R, et al.
Published: (2013)

In vitro enzyme assays for JmjC-domain-containing lysine histone demethylases (JmjC-KDMs)
by: Tarhonskaya, H, et al.
Published: (2018)

JmjC ‐domain‐containing histone demethylases
by: Højrup, C, et al.
Published: (2019)

Inhibitors of JmjC-containing histone demethylases
by: Wright, M, et al.
Published: (2020)

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases.
by: Walport, L, et al.
Published: (2016)

Investigating the inhibitor and substrate diversity of the JmjC histone demethylases
by: Shamo Schiller, R
Published: (2016)

Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66.
by: Türkmen, VA, et al.
Published: (2023)

Analysis of JmjC Demethylase-Catalyzed Demethylation Using Geometrically-Constrained Lysine Analogues
by: Langley, G, et al.
Published: (2015)

Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans
by: Chowdhury, R, et al.
Published: (2022)

Investigating the effect of hypoxia on the JmjC histone lysine demethylase KDM4A
by: Hancock, R
Published: (2016)

A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1.
by: Schiller, R, et al.
Published: (2014)

Biochemical and cellular studies of the KDM6 sub-family of JmjC histone lysine demethylases
by: Dunne, K
Published: (2018)

The catalytic domains of all human KDM5 JmjC demethylases catalyse N-methyl arginine demethylation.
by: Bonnici, J, et al.
Published: (2023)

The activity of JmjC histone lysine demethylase KDM4A is highly sensitive to oxygen concentrations
by: Hancock, R, et al.
Published: (2017)

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.
by: Woon, E, et al.
Published: (2012)

JmjC-domain-containing proteins and histone demethylation.
by: Klose, R, et al.
Published: (2006)

Catalysis by the JmjC histone demethylase KDM4A integrates substrate dynamics, correlated motions and molecular orbital control
by: Ramanan, R, et al.
Published: (2020)

Investigating the substrate selectivity and the inhibitor of the human KDM7 sub-family of JmjC histone lysine demethylases
by: Zhang, Y
Published: (2019)

Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5
by: Tumber, A, et al.
Published: (2023)

Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases
by: Bhushan, B, et al.
Published: (2018)

JMJD8 is a novel endoplasmic reticulum protein with a JmjC domain
by: Yeo, K.S., et al.
Published: (2017)

Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway
by: Hayami, Shinya, et al.
Published: (2010)

JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta.
by: Clissold, P, et al.
Published: (2001)

JMJD5 is a human arginyl C-3 hydroxylase
by: Wilkins, S, et al.
Published: (2018)

Host resistance to a gastrointestinal parasite regulated by Mina, an immunoregulatory member of the JmjC protein family
by: Pillai, MR, et al.
Published: (2013)

2-oxoglutarate-dependent oxygenases
by: Islam, M, et al.
Published: (2018)

JmjC catalysed histone H2a N -methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships
by: Bonnici, J, et al.
Published: (2024)

JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships
by: Bonnici, J
Published: (2024)

Biochemical and biophysical studies on the Jumonji-C hydroxylases JMJD7 and JMJD4
by: Markolovic, S
Published: (2017)

Histone demethylase JmjD2A regulates neural crest specification.
by: Strobl-Mazzulla, P, et al.
Published: (2010)

Structure of proline 3-hydroxylase. Evolution of the family of 2-oxoglutarate dependent oxygenases.
by: Clifton, I, et al.
Published: (2001)

Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH).
by: Schofield, C, et al.
Published: (2007)

Oxygenases for oxygen sensing
by: Loenarz, C, et al.
Published: (2008)

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases
by: Horita, S, et al.
Published: (2015)

Development of biochemical tools to characterise human H3K27 histone demethylase JmjD3
by: Che, KH
Published: (2013)

The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases
by: Markolovic, S, et al.
Published: (2018)

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase.
by: Zhang, Z, et al.
Published: (2011)

Interplay between 2-oxoglutarate oxygenases and cancer: studies on the aspartyl/asparaginyl-beta-hydroxylase
by: Pfeffer, I
Published: (2014)

Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis: anthocyanidin synthase, flavonol synthase, and flavanone 3beta-hydroxylase.
by: Turnbull, J, et al.
Published: (2004)