CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation.
Human NK cells may be divided into a CD56(dim) subset and a CD56(bright) subset. In peripheral blood, CD56(dim) NK cells dominate, whereas in lymph nodes, CD56(bright) NK cells are more common. In this study we show that CD56(bright) NK cells accumulate within inflammatory lesions in a wide variety...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2004
|
| _version_ | 1826284254450941952 |
|---|---|
| author | Dalbeth, N Gundle, R Davies, R Lee, Y Mcmichael, A Callan, M |
| author_facet | Dalbeth, N Gundle, R Davies, R Lee, Y Mcmichael, A Callan, M |
| author_sort | Dalbeth, N |
| collection | OXFORD |
| description | Human NK cells may be divided into a CD56(dim) subset and a CD56(bright) subset. In peripheral blood, CD56(dim) NK cells dominate, whereas in lymph nodes, CD56(bright) NK cells are more common. In this study we show that CD56(bright) NK cells accumulate within inflammatory lesions in a wide variety of clinical diseases affecting several different anatomical sites. We demonstrate that when activated by the monokines IL-12, IL-15, and IL-18, these NK cells promote TNF-alpha production by CD14(+) monocytes in a manner that is dependent on cell:cell contact. Conversely, CD14(+) monocytes synergize with monokines to promote IFN-gamma production by these NK cells. Again, this interaction is dependent on cell:cell contact. The experiments show that CD56(bright) NK cells accumulate in inflammatory lesions and, in the appropriate cytokine environment, can engage with CD14(+) monocytes in a reciprocal activatory fashion, thereby amplifying the inflammatory response. Such a positive feedback loop is likely to be important in the pathogenesis of chronic inflammatory conditions such as rheumatoid arthritis. |
| first_indexed | 2024-03-07T01:11:07Z |
| format | Journal article |
| id | oxford-uuid:8d0ba22e-141b-4c76-8668-a2bd4f34d8fb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:11:07Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:8d0ba22e-141b-4c76-8668-a2bd4f34d8fb2022-03-26T22:48:39ZCD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8d0ba22e-141b-4c76-8668-a2bd4f34d8fbEnglishSymplectic Elements at Oxford2004Dalbeth, NGundle, RDavies, RLee, YMcmichael, ACallan, MHuman NK cells may be divided into a CD56(dim) subset and a CD56(bright) subset. In peripheral blood, CD56(dim) NK cells dominate, whereas in lymph nodes, CD56(bright) NK cells are more common. In this study we show that CD56(bright) NK cells accumulate within inflammatory lesions in a wide variety of clinical diseases affecting several different anatomical sites. We demonstrate that when activated by the monokines IL-12, IL-15, and IL-18, these NK cells promote TNF-alpha production by CD14(+) monocytes in a manner that is dependent on cell:cell contact. Conversely, CD14(+) monocytes synergize with monokines to promote IFN-gamma production by these NK cells. Again, this interaction is dependent on cell:cell contact. The experiments show that CD56(bright) NK cells accumulate in inflammatory lesions and, in the appropriate cytokine environment, can engage with CD14(+) monocytes in a reciprocal activatory fashion, thereby amplifying the inflammatory response. Such a positive feedback loop is likely to be important in the pathogenesis of chronic inflammatory conditions such as rheumatoid arthritis. |
| spellingShingle | Dalbeth, N Gundle, R Davies, R Lee, Y Mcmichael, A Callan, M CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation. |
| title | CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation. |
| title_full | CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation. |
| title_fullStr | CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation. |
| title_full_unstemmed | CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation. |
| title_short | CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation. |
| title_sort | cd56bright nk cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation |
| work_keys_str_mv | AT dalbethn cd56brightnkcellsareenrichedatinflammatorysitesandcanengagewithmonocytesinareciprocalprogramofactivation AT gundler cd56brightnkcellsareenrichedatinflammatorysitesandcanengagewithmonocytesinareciprocalprogramofactivation AT daviesr cd56brightnkcellsareenrichedatinflammatorysitesandcanengagewithmonocytesinareciprocalprogramofactivation AT leey cd56brightnkcellsareenrichedatinflammatorysitesandcanengagewithmonocytesinareciprocalprogramofactivation AT mcmichaela cd56brightnkcellsareenrichedatinflammatorysitesandcanengagewithmonocytesinareciprocalprogramofactivation AT callanm cd56brightnkcellsareenrichedatinflammatorysitesandcanengagewithmonocytesinareciprocalprogramofactivation |