Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004.
OBJECTIVE: To estimate the global and regional distribution of HIV-1 subtypes and recombinants in 2004. DESIGN: A study was conducted in which molecular epidemiological data on HIV-1 subtype distribution in individual countries were combined with country-specific estimates of the number of people l...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2006
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| _version_ | 1797081196345163776 |
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| author | Hemelaar, J Gouws, E Ghys, P Osmanov, S |
| author_facet | Hemelaar, J Gouws, E Ghys, P Osmanov, S |
| author_sort | Hemelaar, J |
| collection | OXFORD |
| description | OBJECTIVE: To estimate the global and regional distribution of HIV-1 subtypes and recombinants in 2004. DESIGN: A study was conducted in which molecular epidemiological data on HIV-1 subtype distribution in individual countries were combined with country-specific estimates of the number of people living with HIV. METHODS: HIV-1 subtype data were collected for 23 874 HIV-1 samples from 70 countries, which together accounted for 89% of all people living with HIV worldwide in 2004. The proportions of HIV-1 infections due to various subtypes detected in each country were combined with the number of HIV infected people in the respective countries to generate regional and global HIV-1 subtype distribution estimates. RESULTS: Subtype C accounted for 50% of all infections worldwide in 2004. Subtypes A, B, D and G accounted for 12%, 10%, 3% and 6%, respectively. The subtypes F, H, J and K together accounted for 0.94% of infections. The circulating recombinant forms CRF01_AE and CRF02_AG each were responsible for 5% of cases, and CRF03_AB for 0.1%. Other recombinants accounted for the remaining 8% of infections. All recombinant forms taken together were responsible for 18% of infections worldwide. CONCLUSION: Combining data on HIV-1 subtype distribution in individual countries with country-specific estimates of the number of people living with HIV provided a good method to generate estimates of the global and regional HIV-1 genetic diversity in 2004. The results could serve as an important resource for HIV scientists, public health officials and HIV vaccine developers. |
| first_indexed | 2024-03-07T01:11:09Z |
| format | Journal article |
| id | oxford-uuid:8d0d9af0-dbad-4109-8fe2-b27f2fb53364 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:11:09Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:8d0d9af0-dbad-4109-8fe2-b27f2fb533642022-03-26T22:48:44ZGlobal and regional distribution of HIV-1 genetic subtypes and recombinants in 2004.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8d0d9af0-dbad-4109-8fe2-b27f2fb53364EnglishSymplectic Elements at Oxford2006Hemelaar, JGouws, EGhys, POsmanov, S OBJECTIVE: To estimate the global and regional distribution of HIV-1 subtypes and recombinants in 2004. DESIGN: A study was conducted in which molecular epidemiological data on HIV-1 subtype distribution in individual countries were combined with country-specific estimates of the number of people living with HIV. METHODS: HIV-1 subtype data were collected for 23 874 HIV-1 samples from 70 countries, which together accounted for 89% of all people living with HIV worldwide in 2004. The proportions of HIV-1 infections due to various subtypes detected in each country were combined with the number of HIV infected people in the respective countries to generate regional and global HIV-1 subtype distribution estimates. RESULTS: Subtype C accounted for 50% of all infections worldwide in 2004. Subtypes A, B, D and G accounted for 12%, 10%, 3% and 6%, respectively. The subtypes F, H, J and K together accounted for 0.94% of infections. The circulating recombinant forms CRF01_AE and CRF02_AG each were responsible for 5% of cases, and CRF03_AB for 0.1%. Other recombinants accounted for the remaining 8% of infections. All recombinant forms taken together were responsible for 18% of infections worldwide. CONCLUSION: Combining data on HIV-1 subtype distribution in individual countries with country-specific estimates of the number of people living with HIV provided a good method to generate estimates of the global and regional HIV-1 genetic diversity in 2004. The results could serve as an important resource for HIV scientists, public health officials and HIV vaccine developers. |
| spellingShingle | Hemelaar, J Gouws, E Ghys, P Osmanov, S Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004. |
| title | Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004. |
| title_full | Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004. |
| title_fullStr | Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004. |
| title_full_unstemmed | Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004. |
| title_short | Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004. |
| title_sort | global and regional distribution of hiv 1 genetic subtypes and recombinants in 2004 |
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