Regulatory impairments following selective 6-OHDA lesions of the neostriatum.
6-Hydroxydopamine lesions of the ventrolateral (VLC) but not anteromedial (AMC) caudate-putamen in rats resulted in a greater post-operative reduction in body weight and water intake than seen in animals with sham lesions. Once animals had fully resumed spontaneous food and water intake, a series of...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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1982
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| _version_ | 1826284256619397120 |
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| author | Dunnett, S Iversen, S |
| author_facet | Dunnett, S Iversen, S |
| author_sort | Dunnett, S |
| collection | OXFORD |
| description | 6-Hydroxydopamine lesions of the ventrolateral (VLC) but not anteromedial (AMC) caudate-putamen in rats resulted in a greater post-operative reduction in body weight and water intake than seen in animals with sham lesions. Once animals had fully resumed spontaneous food and water intake, a series of regulatory challenges were administered, and the AMC rats showed a reduced enhancement of drinking following injection of hypertonic saline. The results are interpreted in terms of a heterogeneous striatal convergence of nigrostriatal and cortical regulatory mechanisms. |
| first_indexed | 2024-03-07T01:11:09Z |
| format | Journal article |
| id | oxford-uuid:8d0daf7f-ceab-4ef7-8784-58a65231da80 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:11:09Z |
| publishDate | 1982 |
| record_format | dspace |
| spelling | oxford-uuid:8d0daf7f-ceab-4ef7-8784-58a65231da802022-03-26T22:48:43ZRegulatory impairments following selective 6-OHDA lesions of the neostriatum.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8d0daf7f-ceab-4ef7-8784-58a65231da80EnglishSymplectic Elements at Oxford1982Dunnett, SIversen, S6-Hydroxydopamine lesions of the ventrolateral (VLC) but not anteromedial (AMC) caudate-putamen in rats resulted in a greater post-operative reduction in body weight and water intake than seen in animals with sham lesions. Once animals had fully resumed spontaneous food and water intake, a series of regulatory challenges were administered, and the AMC rats showed a reduced enhancement of drinking following injection of hypertonic saline. The results are interpreted in terms of a heterogeneous striatal convergence of nigrostriatal and cortical regulatory mechanisms. |
| spellingShingle | Dunnett, S Iversen, S Regulatory impairments following selective 6-OHDA lesions of the neostriatum. |
| title | Regulatory impairments following selective 6-OHDA lesions of the neostriatum. |
| title_full | Regulatory impairments following selective 6-OHDA lesions of the neostriatum. |
| title_fullStr | Regulatory impairments following selective 6-OHDA lesions of the neostriatum. |
| title_full_unstemmed | Regulatory impairments following selective 6-OHDA lesions of the neostriatum. |
| title_short | Regulatory impairments following selective 6-OHDA lesions of the neostriatum. |
| title_sort | regulatory impairments following selective 6 ohda lesions of the neostriatum |
| work_keys_str_mv | AT dunnetts regulatoryimpairmentsfollowingselective6ohdalesionsoftheneostriatum AT iversens regulatoryimpairmentsfollowingselective6ohdalesionsoftheneostriatum |