DCDC2, KIAA0319 and CMIP are associated with reading-related traits.

BACKGROUND: Several susceptibility genes have been proposed for dyslexia (reading disability; RD) and specific language impairment (SLI). RD and SLI show comorbidity, but it is unclear whether a common genetic component is shared. METHODS: We have investigated whether candidate genes for RD and SLI...

Full description

Bibliographic Details
Main Authors: Scerri, T, Morris, A, Buckingham, L, Newbury, D, Miller, L, Monaco, A, Bishop, D, Paracchini, S
Format: Journal article
Language:English
Published: 2011
_version_ 1797081203719798784
author Scerri, T
Morris, A
Buckingham, L
Newbury, D
Miller, L
Monaco, A
Bishop, D
Paracchini, S
author_facet Scerri, T
Morris, A
Buckingham, L
Newbury, D
Miller, L
Monaco, A
Bishop, D
Paracchini, S
author_sort Scerri, T
collection OXFORD
description BACKGROUND: Several susceptibility genes have been proposed for dyslexia (reading disability; RD) and specific language impairment (SLI). RD and SLI show comorbidity, but it is unclear whether a common genetic component is shared. METHODS: We have investigated whether candidate genes for RD and SLI affect specific cognitive traits or have broad effect on cognition. We have analyzed common risk variants within RD (MRPL19/C2ORF3, KIAA0319, and DCDC2) and language impairment (CMIP and ATP2C2) candidate loci in the Avon Longitudinal Study of Parents and Children cohort (n = 3725), representing children born in southwest England in the early 1990s. RESULTS: We detected associations between reading skills and KIAA0319, DCDC2, and CMIP. We show that DCDC2 is specifically associated with RD, whereas variants in CMIP and KIAA0319 are associated with reading skills across the ability range. The strongest associations were restricted to single-word reading and spelling measures, suggesting that these genes do not extend their effect to other reading and language-related skills. Inclusion of individuals with comorbidity tends to strengthen these associations. Our data do not support MRPL19/C2ORF3 as a locus involved in reading abilities nor CMIP/ATP2C2 as genes regulating language skills. CONCLUSIONS: We provide further support for the role of KIAA0319 and DCDC2 in contributing to reading abilities and novel evidence that the language-disorder candidate gene CMIP is also implicated in reading processes. Additionally, we present novel data to evaluate the prevalence and comorbidity of RD and SLI, and we recommend not excluding individuals with comorbid RD and SLI when designing genetic association studies for RD.
first_indexed 2024-03-07T01:11:15Z
format Journal article
id oxford-uuid:8d1624b9-97ab-4c5e-bdbc-7f5a58742e92
institution University of Oxford
language English
last_indexed 2024-03-07T01:11:15Z
publishDate 2011
record_format dspace
spelling oxford-uuid:8d1624b9-97ab-4c5e-bdbc-7f5a58742e922022-03-26T22:48:56ZDCDC2, KIAA0319 and CMIP are associated with reading-related traits.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8d1624b9-97ab-4c5e-bdbc-7f5a58742e92EnglishSymplectic Elements at Oxford2011Scerri, TMorris, ABuckingham, LNewbury, DMiller, LMonaco, ABishop, DParacchini, SBACKGROUND: Several susceptibility genes have been proposed for dyslexia (reading disability; RD) and specific language impairment (SLI). RD and SLI show comorbidity, but it is unclear whether a common genetic component is shared. METHODS: We have investigated whether candidate genes for RD and SLI affect specific cognitive traits or have broad effect on cognition. We have analyzed common risk variants within RD (MRPL19/C2ORF3, KIAA0319, and DCDC2) and language impairment (CMIP and ATP2C2) candidate loci in the Avon Longitudinal Study of Parents and Children cohort (n = 3725), representing children born in southwest England in the early 1990s. RESULTS: We detected associations between reading skills and KIAA0319, DCDC2, and CMIP. We show that DCDC2 is specifically associated with RD, whereas variants in CMIP and KIAA0319 are associated with reading skills across the ability range. The strongest associations were restricted to single-word reading and spelling measures, suggesting that these genes do not extend their effect to other reading and language-related skills. Inclusion of individuals with comorbidity tends to strengthen these associations. Our data do not support MRPL19/C2ORF3 as a locus involved in reading abilities nor CMIP/ATP2C2 as genes regulating language skills. CONCLUSIONS: We provide further support for the role of KIAA0319 and DCDC2 in contributing to reading abilities and novel evidence that the language-disorder candidate gene CMIP is also implicated in reading processes. Additionally, we present novel data to evaluate the prevalence and comorbidity of RD and SLI, and we recommend not excluding individuals with comorbid RD and SLI when designing genetic association studies for RD.
spellingShingle Scerri, T
Morris, A
Buckingham, L
Newbury, D
Miller, L
Monaco, A
Bishop, D
Paracchini, S
DCDC2, KIAA0319 and CMIP are associated with reading-related traits.
title DCDC2, KIAA0319 and CMIP are associated with reading-related traits.
title_full DCDC2, KIAA0319 and CMIP are associated with reading-related traits.
title_fullStr DCDC2, KIAA0319 and CMIP are associated with reading-related traits.
title_full_unstemmed DCDC2, KIAA0319 and CMIP are associated with reading-related traits.
title_short DCDC2, KIAA0319 and CMIP are associated with reading-related traits.
title_sort dcdc2 kiaa0319 and cmip are associated with reading related traits
work_keys_str_mv AT scerrit dcdc2kiaa0319andcmipareassociatedwithreadingrelatedtraits
AT morrisa dcdc2kiaa0319andcmipareassociatedwithreadingrelatedtraits
AT buckinghaml dcdc2kiaa0319andcmipareassociatedwithreadingrelatedtraits
AT newburyd dcdc2kiaa0319andcmipareassociatedwithreadingrelatedtraits
AT millerl dcdc2kiaa0319andcmipareassociatedwithreadingrelatedtraits
AT monacoa dcdc2kiaa0319andcmipareassociatedwithreadingrelatedtraits
AT bishopd dcdc2kiaa0319andcmipareassociatedwithreadingrelatedtraits
AT paracchinis dcdc2kiaa0319andcmipareassociatedwithreadingrelatedtraits