Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection.
Human immunodeficiency virus type 1 (HIV-1) Env-, Gag-, Pol-, Nef-, and Tat-specific cytotoxic T-lymphocyte (CTL) activities were quantitated temporally in five patients with symptomatic primary HIV-1 infection. A dominant CD8(+)-mediated, major histocompatibility complex class I-restricted CTL resp...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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1994
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| _version_ | 1797081206175563776 |
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| author | Borrow, P Lewicki, H Hahn, B Shaw, G Oldstone, M |
| author_facet | Borrow, P Lewicki, H Hahn, B Shaw, G Oldstone, M |
| author_sort | Borrow, P |
| collection | OXFORD |
| description | Human immunodeficiency virus type 1 (HIV-1) Env-, Gag-, Pol-, Nef-, and Tat-specific cytotoxic T-lymphocyte (CTL) activities were quantitated temporally in five patients with symptomatic primary HIV-1 infection. A dominant CD8(+)-mediated, major histocompatibility complex class I-restricted CTL response to the HIV-1 envelope glycoprotein, gp160, was noted in four of the five patients studied. The level of HIV-1-specific CTL activity in the five patients paralleled the efficiency of control of primary viremia. Patients who mounted strong gp160-specific CTL responses showed rapid reduction of acute plasma viremia and antigenemia, while in contrast, primary viremia and antigenemia were poorly controlled in patients in whom virus-specific CTL activity was low or undetectable. These results suggest that HIV-1-specific CTL activity is a major component of the host immune response associated with the control of virus replication following primary HIV-1 infection and have important implications for the design of antiviral vaccines. |
| first_indexed | 2024-03-07T01:11:17Z |
| format | Journal article |
| id | oxford-uuid:8d190823-7a88-4744-9ffd-6f207c1060c8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:11:17Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:8d190823-7a88-4744-9ffd-6f207c1060c82022-03-26T22:49:02ZVirus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8d190823-7a88-4744-9ffd-6f207c1060c8EnglishSymplectic Elements at Oxford1994Borrow, PLewicki, HHahn, BShaw, GOldstone, MHuman immunodeficiency virus type 1 (HIV-1) Env-, Gag-, Pol-, Nef-, and Tat-specific cytotoxic T-lymphocyte (CTL) activities were quantitated temporally in five patients with symptomatic primary HIV-1 infection. A dominant CD8(+)-mediated, major histocompatibility complex class I-restricted CTL response to the HIV-1 envelope glycoprotein, gp160, was noted in four of the five patients studied. The level of HIV-1-specific CTL activity in the five patients paralleled the efficiency of control of primary viremia. Patients who mounted strong gp160-specific CTL responses showed rapid reduction of acute plasma viremia and antigenemia, while in contrast, primary viremia and antigenemia were poorly controlled in patients in whom virus-specific CTL activity was low or undetectable. These results suggest that HIV-1-specific CTL activity is a major component of the host immune response associated with the control of virus replication following primary HIV-1 infection and have important implications for the design of antiviral vaccines. |
| spellingShingle | Borrow, P Lewicki, H Hahn, B Shaw, G Oldstone, M Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. |
| title | Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. |
| title_full | Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. |
| title_fullStr | Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. |
| title_full_unstemmed | Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. |
| title_short | Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. |
| title_sort | virus specific cd8 cytotoxic t lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection |
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