Recoupling the cardiac nitric oxide synthases: Tetrahydrobiopterin synthesis and recycling
Nitric oxide (NO), a key regulator of cardiovascular function, is synthesized from L-arginine and oxygen by the enzyme nitric oxide synthase (NOS). This reaction requires tetrahydrobiopterin (BH4) as a cofactor. BH4 is synthesized from guanosine triphosphate (GTP) by GTP cyclohydrolase I (GTPCH) and...
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| Médium: | Journal article |
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2012
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