Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of Duchenne muscular dystrophy.

Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of Duchenne muscular dystrophy.

A series of novel 2-arylbenzoxazoles that upregulate the production of utrophin in murine H2K cells, as assessed using a luciferase reporter linked assay, have been identified. This compound class appears to hold considerable promise as a potential treatment for Duchenne muscular dystrophy. Followin...

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Bibliographic Details
Main Authors: Chancellor, DR, Davies, K, De Moor, O, Dorgan, C, Johnson, P, Lambert, A, Lawrence, D, Lecci, C, Maillol, C, Middleton, P, Nugent, G, Poignant, S, Potter, A, Price, P, Pye, R, Storer, R, Tinsley, J, van Well, R, Vickers, R, Vile, J, Wilkes, F, Wilson, F, Wren, S, Wynne, G
Format: Journal article
Language:English
Published: 2011

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