A randomised, double-blind, controlled trial of the immunogenicity and tolerability of a meningococcal group C conjugate vaccine in young British infants.
A double-blind, randomised, controlled trial was conducted in 248 British infants to assess the immunogenicity and tolerability of three doses of a meningococcal group C/CRM (197) conjugate vaccine (Lederle Laboratories, USA) given at 2, 3 and 4 months. Control children received three doses of Hepat...
| Үндсэн зохиолчид: | , , , , , , , , , , , |
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| Формат: | Journal article |
| Хэл сонгох: | English |
| Хэвлэсэн: |
2000
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| _version_ | 1826284310366257152 |
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| author | English, M MacLennan, J Bowen-Morris, J Deeks, J Boardman, M Brown, K Smith, S Buttery, J Clarke, J Quataert, S Lockhart, S Moxon, E |
| author_facet | English, M MacLennan, J Bowen-Morris, J Deeks, J Boardman, M Brown, K Smith, S Buttery, J Clarke, J Quataert, S Lockhart, S Moxon, E |
| author_sort | English, M |
| collection | OXFORD |
| description | A double-blind, randomised, controlled trial was conducted in 248 British infants to assess the immunogenicity and tolerability of three doses of a meningococcal group C/CRM (197) conjugate vaccine (Lederle Laboratories, USA) given at 2, 3 and 4 months. Control children received three doses of Hepatitis B vaccine (Engerix B(R); SmithKline Beecham). At 5 months of age, 100% of children receiving the conjugate vaccine had specific immunoglobulin G concentrations >2.0 microg/ml (n=116) compared with only 4% of control children (n=121). Those receiving the conjugate also had 2.5- and 1.6-fold higher geometric mean concentrations of PRP and diphtheria antibodies, respectively. The vaccine was well tolerated. |
| first_indexed | 2024-03-07T01:11:55Z |
| format | Journal article |
| id | oxford-uuid:8d4e109b-d113-4720-94ab-822d1a164de2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:11:55Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:8d4e109b-d113-4720-94ab-822d1a164de22022-03-26T22:50:22ZA randomised, double-blind, controlled trial of the immunogenicity and tolerability of a meningococcal group C conjugate vaccine in young British infants.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8d4e109b-d113-4720-94ab-822d1a164de2EnglishSymplectic Elements at Oxford2000English, MMacLennan, JBowen-Morris, JDeeks, JBoardman, MBrown, KSmith, SButtery, JClarke, JQuataert, SLockhart, SMoxon, EA double-blind, randomised, controlled trial was conducted in 248 British infants to assess the immunogenicity and tolerability of three doses of a meningococcal group C/CRM (197) conjugate vaccine (Lederle Laboratories, USA) given at 2, 3 and 4 months. Control children received three doses of Hepatitis B vaccine (Engerix B(R); SmithKline Beecham). At 5 months of age, 100% of children receiving the conjugate vaccine had specific immunoglobulin G concentrations >2.0 microg/ml (n=116) compared with only 4% of control children (n=121). Those receiving the conjugate also had 2.5- and 1.6-fold higher geometric mean concentrations of PRP and diphtheria antibodies, respectively. The vaccine was well tolerated. |
| spellingShingle | English, M MacLennan, J Bowen-Morris, J Deeks, J Boardman, M Brown, K Smith, S Buttery, J Clarke, J Quataert, S Lockhart, S Moxon, E A randomised, double-blind, controlled trial of the immunogenicity and tolerability of a meningococcal group C conjugate vaccine in young British infants. |
| title | A randomised, double-blind, controlled trial of the immunogenicity and tolerability of a meningococcal group C conjugate vaccine in young British infants. |
| title_full | A randomised, double-blind, controlled trial of the immunogenicity and tolerability of a meningococcal group C conjugate vaccine in young British infants. |
| title_fullStr | A randomised, double-blind, controlled trial of the immunogenicity and tolerability of a meningococcal group C conjugate vaccine in young British infants. |
| title_full_unstemmed | A randomised, double-blind, controlled trial of the immunogenicity and tolerability of a meningococcal group C conjugate vaccine in young British infants. |
| title_short | A randomised, double-blind, controlled trial of the immunogenicity and tolerability of a meningococcal group C conjugate vaccine in young British infants. |
| title_sort | randomised double blind controlled trial of the immunogenicity and tolerability of a meningococcal group c conjugate vaccine in young british infants |
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