The head's tale: Anterior-posterior axis formation in the mouse embryo.
The establishment of the anterior-posterior (A-P) axis is a fundamental event during early development and marks the start of the process by which the basic body plan is laid down. This axial information determines where gastrulation, that generates and positions cells of the three-germ layers, occu...
| Main Authors: | , |
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| Format: | Book section |
| Language: | English |
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Elsevier
2017
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| _version_ | 1797081294128021504 |
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| author | Stower, M Srinivas, S |
| author_facet | Stower, M Srinivas, S |
| author_sort | Stower, M |
| collection | OXFORD |
| description | The establishment of the anterior-posterior (A-P) axis is a fundamental event during early development and marks the start of the process by which the basic body plan is laid down. This axial information determines where gastrulation, that generates and positions cells of the three-germ layers, occurs. A-P patterning requires coordinated interactions between multiple tissues, tight spatiotemporal control of signaling pathways, and the coordination of tissue growth with morphogenetic movements. In the mouse, a specialized population of cells, the anterior visceral endoderm (AVE) undergoes a migration event critical for correct A-P pattern. In this review, we summarize our understanding of the generation of anterior pattern, focusing on the role of the AVE. We will also outline some of the many questions that remain regarding the mechanism by which the first axial asymmetry is established, how the AVE is induced, and how it moves within the visceral endoderm epithelium. |
| first_indexed | 2024-03-07T01:12:35Z |
| format | Book section |
| id | oxford-uuid:8d8b5c6b-d4a1-4c22-ac94-a5ee115bfd54 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:12:35Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:8d8b5c6b-d4a1-4c22-ac94-a5ee115bfd542022-03-26T22:51:50ZThe head's tale: Anterior-posterior axis formation in the mouse embryo.Book sectionhttp://purl.org/coar/resource_type/c_3248uuid:8d8b5c6b-d4a1-4c22-ac94-a5ee115bfd54EnglishSymplectic Elements at OxfordElsevier2017Stower, MSrinivas, SThe establishment of the anterior-posterior (A-P) axis is a fundamental event during early development and marks the start of the process by which the basic body plan is laid down. This axial information determines where gastrulation, that generates and positions cells of the three-germ layers, occurs. A-P patterning requires coordinated interactions between multiple tissues, tight spatiotemporal control of signaling pathways, and the coordination of tissue growth with morphogenetic movements. In the mouse, a specialized population of cells, the anterior visceral endoderm (AVE) undergoes a migration event critical for correct A-P pattern. In this review, we summarize our understanding of the generation of anterior pattern, focusing on the role of the AVE. We will also outline some of the many questions that remain regarding the mechanism by which the first axial asymmetry is established, how the AVE is induced, and how it moves within the visceral endoderm epithelium. |
| spellingShingle | Stower, M Srinivas, S The head's tale: Anterior-posterior axis formation in the mouse embryo. |
| title | The head's tale: Anterior-posterior axis formation in the mouse embryo. |
| title_full | The head's tale: Anterior-posterior axis formation in the mouse embryo. |
| title_fullStr | The head's tale: Anterior-posterior axis formation in the mouse embryo. |
| title_full_unstemmed | The head's tale: Anterior-posterior axis formation in the mouse embryo. |
| title_short | The head's tale: Anterior-posterior axis formation in the mouse embryo. |
| title_sort | head s tale anterior posterior axis formation in the mouse embryo |
| work_keys_str_mv | AT stowerm theheadstaleanteriorposterioraxisformationinthemouseembryo AT srinivass theheadstaleanteriorposterioraxisformationinthemouseembryo AT stowerm headstaleanteriorposterioraxisformationinthemouseembryo AT srinivass headstaleanteriorposterioraxisformationinthemouseembryo |