Haem oxygenase-1 induction reverses the actions of interleukin-1β on hypoxia-inducible transcription factors and human chondrocyte metabolism in hypoxia.

Haem oxygenase-1 induction reverses the actions of interleukin-1β on hypoxia-inducible transcription factors and human chondrocyte metabolism in hypoxia.

HO-1 (haem oxygenase-1) catalyses the degradation of haem and possesses anti-inflammatory and cytoprotective properties. The role of inflammatory mediators in the pathogenesis of OA (osteoarthritis) is becoming increasingly appreciated. In the present study, we investigated the effects of HO-1 induc...

ver descrição completa

Detalhes bibliográficos
Principais autores:	Clérigues, V, Murphy, C, Guillén, M, Alcaraz, M
Formato:	Journal article
Idioma:	English
Publicado em:	2013

Registros relacionados

Studies on non-haem ferrous-dependent oxygenases and oxidases.
por: Barlow, J, et al.
Publicado em: (1997)

The Anti-Inflammatory Effects of Dimethyl Fumarate in Astrocytes Involve Glutathione and Haem Oxygenase-1
por: Shao Xia Lin, et al.
Publicado em: (2011-03-01)

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
por: Frezza, C, et al.
Publicado em: (2011)

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
por: Frezza, C, et al.
Publicado em: (2011)

Hypoxia-inducible factor 2alpha is essential for hypoxic induction of the human articular chondrocyte phenotype.
por: Lafont, J, et al.
Publicado em: (2007)

Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.
por: Hewitson, K, et al.
Publicado em: (2005)

Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair.
por: Murphy, C, et al.
Publicado em: (2009)

Nitric oxide synthase is downregulated, while haem oxygenase is increased, in patients with septic shock.
por: Reade, M, et al.
Publicado em: (2005)

Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
por: Wiesener, MS, et al.
Publicado em: (1998)

High expression levels of haem oxygenase-1 promote ferroptosis in macrophage-derived foam cells and exacerbate plaque instability
por: Zhenyu Guo, et al.
Publicado em: (2024-10-01)

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia.
por: Fang, H, et al.
Publicado em: (2009)

Rapid effects of hypoxia on H+ homeostasis in articular chondrocytes.
por: Gibson, J, et al.
Publicado em: (2009)

Interleukin-1β Affects MDAMB231 Breast Cancer Cell Migration under Hypoxia: Role of HIF-1α and NFκB Transcription Factors
por: Irene Filippi, et al.
Publicado em: (2015-01-01)

Conditioned Media from Adipose-Tissue-Derived Mesenchymal Stem Cells Downregulate Degradative Mediators Induced by Interleukin-1β in Osteoarthritic Chondrocytes
por: Julia Platas, et al.
Publicado em: (2013-01-01)

Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.
por: Sowter, H, et al.
Publicado em: (2003)

The role of hypoxia-inducible H19-derived miR-675 in promoting chondrocyte function
por: Murphy, C, et al.
Publicado em: (2009)

Interleukin-37 Inhibits Interleukin-1β-Induced Articular Chondrocyte Apoptosis by Suppressing Reactive Oxygen Species
por: Seong-Kyu Kim, et al.
Publicado em: (2024-09-01)

The sensitivity of acute myeloid leukemia cells to cytarabine is increased by suppressing the expression of Heme oxygenase-1 and hypoxia-inducible factor 1-alpha
por: Mohammad Sadeghi, et al.
Publicado em: (2024-06-01)

Parathyroid hormone-related protein is induced by hypoxia and promotes expression of the differentiated phenotype of human articular chondrocytes.
por: Pelosi, M, et al.
Publicado em: (2013)

Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways.
por: Lafont, J, et al.
Publicado em: (2008)

Silencing of hypoxia-inducible factor-1β induces anti-tumor effects in hepatoma cell lines under tumor hypoxia.
por: Sung Hoon Choi, et al.
Publicado em: (2014-01-01)

Screening of Hypoxia-Sensitive and Hypoxia-Tolerant Wistar Rats and Preliminary Exploration of Hypoxia Sensitivity in Their G1 Generation
por: XIAO Pan, et al.
Publicado em: (2024-08-01)

Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin
por: Eric M. George, et al.
Publicado em: (2012-01-01)

Investigating the transcriptional response of rDNA to hypoxia
por: Ng, N
Publicado em: (2021)

Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: evidence against a regulatory role for Src kinase.
por: Gleadle, J, et al.
Publicado em: (1997)

Comparison of Concentration- and Homology-Dependent Effects of the Proinflammatory Cytokine Interleukin-1β (IL-1β) in a Bovine Chondrocyte Inflammation Model
por: Robert Ossendorff, et al.
Publicado em: (2024-12-01)

Correlation Analysis of Serum Lipopolysaccharide, Nuclear Factor Erythroid 2-Related Factor 2 and Haem Oxygenase 1 Levels and Cognitive Impairment in Patients with Obstructive Sleep Apnoea
por: Feng G, et al.
Publicado em: (2024-05-01)

Cerebral heme oxygenase 1 and 2 spatial distribution is modulated following injury from hypoxia-ischemia and middle cerebral artery occlusion in rats.
por: Sutherland, B, et al.
Publicado em: (2009)

The hypoxia response pathway and β-cell function.
por: Cantley, J, et al.
Publicado em: (2010)

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts.
por: Mole, D, et al.
Publicado em: (2009)

Interleukin IL-1β stimulates revitalization of cartilage matrix <i>in vitro</i> with human nasal chondrocytes
por: D. S. Baranovsky, et al.
Publicado em: (2020-02-01)

Arctiin Protects Chondrocytes from Interleukin-1β-Induced Inflammation and Apoptosis by RNA Sequence In vivo and In vitro
por: Yong-Jia Song, et al.
Publicado em: (2024-12-01)

Protective effect of clusterin against interleukin‐1β‐induced apoptosis and inflammation in human knee osteoarthritis chondrocytes
por: Tachatra Ungsudechachai, et al.
Publicado em: (2024-07-01)

Induction of nitric oxide synthase and interleukin-1beta, but not heme oxygenase, messenger RNA in rat brain following peripheral administration of endotoxin.
por: Jacobs, R, et al.
Publicado em: (1997)

Pan-genomic binding of hypoxia-inducible transcription factors.
por: Schödel, J, et al.
Publicado em: (2013)

The spectra of ferric haems and haemoproteins /
por: Hemmerich, P.
Publicado em: (1970)

Haem disorder in modified myoglobins
por: Ahmad, Mansor, et al.
Publicado em: (1983)

Expression of the forkhead transcription factor FOXP1 is associated both with hypoxia inducible factors (HIFs) and the androgen receptor in prostate cancer but is not directly regulated by androgens or hypoxia.
por: Banham, A, et al.
Publicado em: (2007)

The effect of hyaluronic acid on nucleus pulposus extracellular matrix production through hypoxia-inducible factor-1α transcriptional activation of CD44 under hypoxia
por: F Zhang, et al.
Publicado em: (2021-02-01)

Epigallocatechin Gallate Attenuates Proliferation and Oxidative Stress in Human Vascular Smooth Muscle Cells Induced by Interleukin-1β via Heme Oxygenase-1
por: Po-Len Liu, et al.
Publicado em: (2014-01-01)