High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans

High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans

The ontogeny of the natural, public IgM repertoire remains incompletely explored. Here, high-resolution immunogenetic analysis of B cells from (unrelated) fetal, child, and adult samples, shows that although fetal liver (FL) and bone marrow (FBM) IgM repertoires are equally diversified, FL is the ma...

Bibliografiset tiedot
Päätekijät:	Roy, A, Bystry, V, Bohn, G, Goudevenou, K, Reigl, T, Papaioannou, M, Krejci, A, O'Byrne, S, Chaidos, A, Grioni, A, Darzentas, N, Roberts, I, Karadimitris, A
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	Elsevier 2017

Samankaltaisia teoksia

High Resolution Igh Repertoire Analysis Reveals the Human Fetal Liver As the Origin of Life-Long, Innate B Lymphopoiesis
Tekijä: Roy, A, et al.
Julkaistu: (2016)

Human fetal B-lymphopoiesis and acute lymphoblastic leukaemia: the impact of trisomy 21
Tekijä: O'Byrne, S
Julkaistu: (2019)

Different B cell subpopulations show distinct patterns in their IgH repertoire metrics
Tekijä: Ghraichy, M, et al.
Julkaistu: (2021)

Different B cell subpopulations show distinct patterns in their IgH repertoire metrics
Tekijä: Marie Ghraichy, et al.
Julkaistu: (2021-10-01)

Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires
Tekijä: Yang Yang, et al.
Julkaistu: (2015-09-01)

Igh Locus Polymorphism May Dictate Topological Chromatin Conformation and V Gene Usage in the Ig Repertoire
Tekijä: Amy L. Kenter, et al.
Julkaistu: (2021-05-01)

Landscape of IGH germline genes of Chiroptera and the pattern of Rhinolophus affinis bat IGH CDR3 repertoire
Tekijä: Long Ma, et al.
Julkaistu: (2024-04-01)

BONE MARROW HAEMATOPOIESIS IN THE SECOND TRIMESTER OF FETAL LIFE IS STRONGLY BIASED TOWARDS B-LYMPHOPOIESIS AND IS SEVERELY IMPAIRED AT THE EBP-CBP TRANSITION IN DOWN SYNDROME
Tekijä: Roy, A, et al.
Julkaistu: (2010)

Misregulation of the IgH Locus in Thymocytes
Tekijä: Gita Kumari, et al.
Julkaistu: (2018-11-01)

Production of Antigen-Specific Human Monoclonal Antibodies: Comparison of Mice Carrying IgH/κ or IgH/κ/λ Transloci
Tekijä: S. Magadán, et al.
Julkaistu: (2002-09-01)

Balancing proliferation with Igκ recombination during B lymphopoiesis
Tekijä: Keith Michael Hamel, et al.
Julkaistu: (2014-04-01)

Age-related changes in human peripheral blood IGH repertoire following vaccination
Tekijä: Yu-Chang Bryan Wu, et al.
Julkaistu: (2012-07-01)

The fetal specific gene LIN28B is essential for human fetal b-lymphopoiesis and initiation of KMT2A-AFF1+ infant acute lymphoblastic leukemia
Tekijä: Ling, RE, et al.
Julkaistu: (2024)

Evolution of duplicated <it>IgH </it>loci in Atlantic salmon, <it>Salmo salar</it>
Tekijä: Yasuike Motoshige, et al.
Julkaistu: (2010-09-01)

Trisomy 21 driven pro-inflammatory signalling in fetal bone marrow may play a role in perturbed B-lymphopoiesis and acute lymphoblastic leukemia of Down syndrome
Tekijä: O'Byrne, SI, et al.
Julkaistu: (2019)

Lycopene induces bone marrow lymphopoiesis and differentiation of peritoneal IgA-producing cells
Tekijä: MONIQUE B. ELIAS, et al.
Julkaistu: (2022-10-01)

The cellular and molecular basis of defects in Down syndrome fetal bone marrow B-lymphopoiesis
Tekijä: Murnane, C
Julkaistu: (2022)

Three IgH isotypes, IgM, IgA and IgY are expressed in Gentoo penguin and zebra finch.
Tekijä: Binyue Han, et al.
Julkaistu: (2017-01-01)

IgH Diversity In an Individual With Only One Million B Lymphocytes
Tekijä: Ada Lee, et al.
Julkaistu: (1993-01-01)

Human invariant NKT cells display alloreactivity instructed by invariant TCR-CD1d interaction and killer Ig receptors
Tekijä: Patterson, S, et al.
Julkaistu: (2008)

Human invariant NKT cells display alloreactivity instructed by invariant TCR-CD1d interaction and killer Ig receptors.
Tekijä: Patterson, S, et al.
Julkaistu: (2008)

Mystifying Molecular Structure, Expression and Repertoire Diversity of IgM Heavy Chain Genes (Ighμ) in Clarias Catfish and Hybrids: Two Novel Transcripts in Vertebrates
Tekijä: Anurak Bunnoy, et al.
Julkaistu: (2022-06-01)

Transcriptome and IgH Repertoire Analyses Show That CD11chi B Cells Are a Distinct Population With Similarity to B Cells Arising in Autoimmunity and Infection
Tekijä: Robert W. Maul, et al.
Julkaistu: (2021-03-01)

Unravelling the molecular and cellular mechanisms of fetal B cell lymphopoiesis to help understand childhood leukaemia
Tekijä: Green, J
Julkaistu: (2015)

IgH 3' regulatory region increases ectopic class switch recombination.
Tekijä: Sandrine Le Noir, et al.
Julkaistu: (2021-02-01)

Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus.
Tekijä: Thomas Perlot, et al.
Julkaistu: (2010-11-01)

Genome wide dysregulation of gene expression by Trisomy 21 in fetal liver haematopoietic stem and progenitor cells
Tekijä: Roy, A, et al.
Julkaistu: (2016)

Standardized IMGT® Nomenclature of Salmonidae IGH Genes, the Paradigm of Atlantic Salmon and Rainbow Trout: From Genomics to Repertoires
Tekijä: Susana Magadan, et al.
Julkaistu: (2019-11-01)

IGH rearrangement in myeloid neoplasms
Tekijä: Amy W. Xiao, et al.
Julkaistu: (2020-06-01)

Axin2/Conductin Is Required for Normal Haematopoiesis and T Lymphopoiesis
Tekijä: Jolanda J. D. de Roo, et al.
Julkaistu: (2022-08-01)

Microbiota Signals Suppress B Lymphopoiesis With Aging in Mice
Tekijä: Joseph R. Krambs, et al.
Julkaistu: (2021-10-01)

Dutcher bodies in an IgA‐myeloma patient harbouring the FGFR3/IGH fusion
Tekijä: Masahiro Manabe, et al.
Julkaistu: (2023-05-01)

Insights into IGH clonal evolution in BCP-ALL: frequency, mechanisms, associations, and diagnostic implications
Tekijä: Franziska Darzentas, et al.
Julkaistu: (2023-04-01)

High-Oxygen Submersion Fetal Thymus Organ Cultures Enable FOXN1-Dependent and -Independent Support of T Lymphopoiesis
Tekijä: Jianxun Han, et al.
Julkaistu: (2021-03-01)

B-cell lymphopoiesis is regulated by cathepsin L.
Tekijä: Maria Noel Badano, et al.
Julkaistu: (2013-01-01)

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21
Tekijä: Roy, A, et al.
Julkaistu: (2012)

Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma
Tekijä: Tianyi Ye, et al.
Julkaistu: (2024-05-01)

T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis.
Tekijä: Viki Bockstal, et al.
Julkaistu: (2011-06-01)

IGH Rearrangement Evolution in Adult KMT2A-rearranged B-cell Precursor ALL: Implications for Cell-of-origin and MRD Monitoring
Tekijä: Franziska Darzentas, et al.
Julkaistu: (2023-01-01)

Eμ and 3′RR IgH enhancers show hierarchic unilateral dependence in mature B-cells
Tekijä: A. Saintamand, et al.
Julkaistu: (2017-03-01)