Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates.
The RNA-dependent RNA polymerase of influenza A virus is responsible for both transcription and replication of negative-sense viral RNA. It is thought that a "switching" mechanism regulates the transition between these activities. We demonstrate that, in the presence of preexisting viral R...
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1826284379385626624 |
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| author | Vreede, F Jung, T Brownlee, G |
| author_facet | Vreede, F Jung, T Brownlee, G |
| author_sort | Vreede, F |
| collection | OXFORD |
| description | The RNA-dependent RNA polymerase of influenza A virus is responsible for both transcription and replication of negative-sense viral RNA. It is thought that a "switching" mechanism regulates the transition between these activities. We demonstrate that, in the presence of preexisting viral RNA polymerase and nucleoprotein (NP), influenza A virus synthesizes both mRNA (transcription) and cRNA (replication) early in infection. We suggest that there may be no switch regulating the initiation of RNA synthesis and present a model suggesting that nascent cRNA is degraded by host cell nucleases unless it is stabilized by newly synthesized viral RNA polymerase and NP. |
| first_indexed | 2024-03-07T01:12:57Z |
| format | Journal article |
| id | oxford-uuid:8da739be-e855-4084-ab42-c1a02ff467fb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:12:57Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:8da739be-e855-4084-ab42-c1a02ff467fb2022-03-26T22:52:39ZModel suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8da739be-e855-4084-ab42-c1a02ff467fbEnglishSymplectic Elements at Oxford2004Vreede, FJung, TBrownlee, GThe RNA-dependent RNA polymerase of influenza A virus is responsible for both transcription and replication of negative-sense viral RNA. It is thought that a "switching" mechanism regulates the transition between these activities. We demonstrate that, in the presence of preexisting viral RNA polymerase and nucleoprotein (NP), influenza A virus synthesizes both mRNA (transcription) and cRNA (replication) early in infection. We suggest that there may be no switch regulating the initiation of RNA synthesis and present a model suggesting that nascent cRNA is degraded by host cell nucleases unless it is stabilized by newly synthesized viral RNA polymerase and NP. |
| spellingShingle | Vreede, F Jung, T Brownlee, G Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates. |
| title | Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates. |
| title_full | Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates. |
| title_fullStr | Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates. |
| title_full_unstemmed | Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates. |
| title_short | Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates. |
| title_sort | model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates |
| work_keys_str_mv | AT vreedef modelsuggestingthatreplicationofinfluenzavirusisregulatedbystabilizationofreplicativeintermediates AT jungt modelsuggestingthatreplicationofinfluenzavirusisregulatedbystabilizationofreplicativeintermediates AT brownleeg modelsuggestingthatreplicationofinfluenzavirusisregulatedbystabilizationofreplicativeintermediates |