Catalytic enantioselective 6π photocyclization of acrylanilides and enantiomerisation processes of indolyl-napthyl atropisomers
<p>This thesis is composed of two parts. The first part describes the development of a dual catalytic enantioselective 6π photocyclization (Scheme A1).</p> <p>We go on to describe the work carried out to validate the predicted reaction pathway and determine whether the photocataly...
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| Format: | Thesis |
| Language: | English |
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2023
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| Summary: | <p>This thesis is composed of two parts. The first part describes the development of a dual catalytic enantioselective 6π photocyclization (Scheme A1).</p>
<p>We go on to describe the work carried out to validate the predicted reaction pathway and determine whether the photocatalytic portion of the cycle operates by photoredox catalysis or energy transfer catalysis (Figure A1).</p>
<p>The second part describes the observation of non-first order racemisation of an indolyl-naphthyl atropisomer and the work carried out to reproducibly observe the effect and gather data across a number of concentrations (Figure A2).</p>
<p>We then describe the combination of experimental probes and modelling carried out in the hopes of determining the underlying cause of the observed behaviour (Figure A3).</p> |
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