Preliminary studies on the transformation of nitrosugars into branched chain iminosugars: synthesis of 1,4-dideoxy-4-C-hydroxymethyl-1,4-imino-pentanols.
A novel promising strategy for the transformation of nitrosugars into branched pyrrolidines, based on double Henry reaction with formaldehyde followed by reductive ring closure, allowed the first enantiospecific synthesis of a 4-C-hydroxymethyl branched derivative of the well-known glycosidase inhib...
| Main Authors: | , , , , , , , |
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
2007
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| _version_ | 1826284413598564352 |
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| author | Otero, J Soengas, R Estévez, J Estévez, R Watkin, D Evinson, E Nash, R Fleet, G |
| author_facet | Otero, J Soengas, R Estévez, J Estévez, R Watkin, D Evinson, E Nash, R Fleet, G |
| author_sort | Otero, J |
| collection | OXFORD |
| description | A novel promising strategy for the transformation of nitrosugars into branched pyrrolidines, based on double Henry reaction with formaldehyde followed by reductive ring closure, allowed the first enantiospecific synthesis of a 4-C-hydroxymethyl branched derivative of the well-known glycosidase inhibitor 1,4-dideoxy-1,4-imino-pentanol. This strategy also afforded a new route to some other interesting derivatives, such as N-hydroxy, N-propyloxy, and imino derivatives, a new kind of compounds with promising biological properties. [reaction: see text]. |
| first_indexed | 2024-03-07T01:13:28Z |
| format | Journal article |
| id | oxford-uuid:8dd89985-441f-42b5-9801-7ad33e67bbb6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:13:28Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:8dd89985-441f-42b5-9801-7ad33e67bbb62022-03-26T22:53:45ZPreliminary studies on the transformation of nitrosugars into branched chain iminosugars: synthesis of 1,4-dideoxy-4-C-hydroxymethyl-1,4-imino-pentanols.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8dd89985-441f-42b5-9801-7ad33e67bbb6EnglishSymplectic Elements at Oxford2007Otero, JSoengas, REstévez, JEstévez, RWatkin, DEvinson, ENash, RFleet, GA novel promising strategy for the transformation of nitrosugars into branched pyrrolidines, based on double Henry reaction with formaldehyde followed by reductive ring closure, allowed the first enantiospecific synthesis of a 4-C-hydroxymethyl branched derivative of the well-known glycosidase inhibitor 1,4-dideoxy-1,4-imino-pentanol. This strategy also afforded a new route to some other interesting derivatives, such as N-hydroxy, N-propyloxy, and imino derivatives, a new kind of compounds with promising biological properties. [reaction: see text]. |
| spellingShingle | Otero, J Soengas, R Estévez, J Estévez, R Watkin, D Evinson, E Nash, R Fleet, G Preliminary studies on the transformation of nitrosugars into branched chain iminosugars: synthesis of 1,4-dideoxy-4-C-hydroxymethyl-1,4-imino-pentanols. |
| title | Preliminary studies on the transformation of nitrosugars into branched chain iminosugars: synthesis of 1,4-dideoxy-4-C-hydroxymethyl-1,4-imino-pentanols. |
| title_full | Preliminary studies on the transformation of nitrosugars into branched chain iminosugars: synthesis of 1,4-dideoxy-4-C-hydroxymethyl-1,4-imino-pentanols. |
| title_fullStr | Preliminary studies on the transformation of nitrosugars into branched chain iminosugars: synthesis of 1,4-dideoxy-4-C-hydroxymethyl-1,4-imino-pentanols. |
| title_full_unstemmed | Preliminary studies on the transformation of nitrosugars into branched chain iminosugars: synthesis of 1,4-dideoxy-4-C-hydroxymethyl-1,4-imino-pentanols. |
| title_short | Preliminary studies on the transformation of nitrosugars into branched chain iminosugars: synthesis of 1,4-dideoxy-4-C-hydroxymethyl-1,4-imino-pentanols. |
| title_sort | preliminary studies on the transformation of nitrosugars into branched chain iminosugars synthesis of 1 4 dideoxy 4 c hydroxymethyl 1 4 imino pentanols |
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