Monocyte dysfunction, activation, and inflammation after long-term antiretroviral therapy in an African cohort
BACKGROUND: Monocyte dysfunction may persist during antiretroviral therapy (ART). METHODS: Frozen peripheral blood mononuclear cells of 30 human immunodeficiency virus (HIV)-infected ART-treated adults with sustained viral suppression and CD4 counts ≥500 cells/µL were consecutively analyzed for mono...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2019
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| _version_ | 1826284426324082688 |
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| author | Nabatanzi, R Bayigga, L Cose, S Rowland Jones, S Joloba, M Canderan, G Nakanjako, D |
| author_facet | Nabatanzi, R Bayigga, L Cose, S Rowland Jones, S Joloba, M Canderan, G Nakanjako, D |
| author_sort | Nabatanzi, R |
| collection | OXFORD |
| description | BACKGROUND: Monocyte dysfunction may persist during antiretroviral therapy (ART). METHODS: Frozen peripheral blood mononuclear cells of 30 human immunodeficiency virus (HIV)-infected ART-treated adults with sustained viral suppression and CD4 counts ≥500 cells/µL were consecutively analyzed for monocyte phenotypes and function. RESULTS: Nonclassical monocytes (CD14+, CD16++), interleukin (IL)-1β production, and expression of CD40 and CD86 were lower among ART-treated HIV-infected adults relative to age-matched HIV-negative adults (P = .01, P = .01, and P = .02, respectively). Intestinal fatty acid-binding protein, IL6, and soluble CD14 were higher among HIV-infected adults relative to HIV-negative adults (P = .0002, P = .04, and P = .0017, respectively). CONCLUSIONS: Further investigation is required to understand drivers of persistent monocyte activation and dysfunction. |
| first_indexed | 2024-03-07T01:13:40Z |
| format | Journal article |
| id | oxford-uuid:8de6ad42-4827-4712-aca4-00c177b6437a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:13:40Z |
| publishDate | 2019 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:8de6ad42-4827-4712-aca4-00c177b6437a2022-03-26T22:54:09ZMonocyte dysfunction, activation, and inflammation after long-term antiretroviral therapy in an African cohortJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8de6ad42-4827-4712-aca4-00c177b6437aEnglishSymplectic Elements at OxfordOxford University Press2019Nabatanzi, RBayigga, LCose, SRowland Jones, SJoloba, MCanderan, GNakanjako, DBACKGROUND: Monocyte dysfunction may persist during antiretroviral therapy (ART). METHODS: Frozen peripheral blood mononuclear cells of 30 human immunodeficiency virus (HIV)-infected ART-treated adults with sustained viral suppression and CD4 counts ≥500 cells/µL were consecutively analyzed for monocyte phenotypes and function. RESULTS: Nonclassical monocytes (CD14+, CD16++), interleukin (IL)-1β production, and expression of CD40 and CD86 were lower among ART-treated HIV-infected adults relative to age-matched HIV-negative adults (P = .01, P = .01, and P = .02, respectively). Intestinal fatty acid-binding protein, IL6, and soluble CD14 were higher among HIV-infected adults relative to HIV-negative adults (P = .0002, P = .04, and P = .0017, respectively). CONCLUSIONS: Further investigation is required to understand drivers of persistent monocyte activation and dysfunction. |
| spellingShingle | Nabatanzi, R Bayigga, L Cose, S Rowland Jones, S Joloba, M Canderan, G Nakanjako, D Monocyte dysfunction, activation, and inflammation after long-term antiretroviral therapy in an African cohort |
| title | Monocyte dysfunction, activation, and inflammation after long-term antiretroviral therapy in an African cohort |
| title_full | Monocyte dysfunction, activation, and inflammation after long-term antiretroviral therapy in an African cohort |
| title_fullStr | Monocyte dysfunction, activation, and inflammation after long-term antiretroviral therapy in an African cohort |
| title_full_unstemmed | Monocyte dysfunction, activation, and inflammation after long-term antiretroviral therapy in an African cohort |
| title_short | Monocyte dysfunction, activation, and inflammation after long-term antiretroviral therapy in an African cohort |
| title_sort | monocyte dysfunction activation and inflammation after long term antiretroviral therapy in an african cohort |
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