Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia.
Oral chloroquine is the treatment of choice for uncomplicated Plasmodium malariae infections worldwide. We did a prospective 28-day in-vivo assessment of the efficacy of chloroquine for treatment of P malariae on Legundi Island in Lampung Bay, Sumatra, Indonesia. Of 28 patients, one had recurrent pa...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Sprog: | English |
| Udgivet: |
2002
|
| _version_ | 1826284429316718592 |
|---|---|
| author | Maguire, J Sumawinata, I Masbar, S Laksana, B Prodjodipuro, P Susanti, I Sismadi, P Mahmud, N Bangs, M Baird, J |
| author_facet | Maguire, J Sumawinata, I Masbar, S Laksana, B Prodjodipuro, P Susanti, I Sismadi, P Mahmud, N Bangs, M Baird, J |
| author_sort | Maguire, J |
| collection | OXFORD |
| description | Oral chloroquine is the treatment of choice for uncomplicated Plasmodium malariae infections worldwide. We did a prospective 28-day in-vivo assessment of the efficacy of chloroquine for treatment of P malariae on Legundi Island in Lampung Bay, Sumatra, Indonesia. Of 28 patients, one had recurrent parasitaemia on day 28, and two had persistent parasitaemia to day 8. Whole-blood chloroquine and desethylchloroquine concentrations were at ordinarily effective levels (> or = 100 microg/L) on day 8 in both cases of persistent parasitaemia. These findings suggest that clinical resistance to chloroquine by P malariae occurs in the Indonesian archipelago of southeast Asia. |
| first_indexed | 2024-03-07T01:13:42Z |
| format | Journal article |
| id | oxford-uuid:8dec3ebf-e99e-4f2c-bbb3-fa76fa2d7b9d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:13:42Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:8dec3ebf-e99e-4f2c-bbb3-fa76fa2d7b9d2022-03-26T22:54:15ZChloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8dec3ebf-e99e-4f2c-bbb3-fa76fa2d7b9dEnglishSymplectic Elements at Oxford2002Maguire, JSumawinata, IMasbar, SLaksana, BProdjodipuro, PSusanti, ISismadi, PMahmud, NBangs, MBaird, JOral chloroquine is the treatment of choice for uncomplicated Plasmodium malariae infections worldwide. We did a prospective 28-day in-vivo assessment of the efficacy of chloroquine for treatment of P malariae on Legundi Island in Lampung Bay, Sumatra, Indonesia. Of 28 patients, one had recurrent parasitaemia on day 28, and two had persistent parasitaemia to day 8. Whole-blood chloroquine and desethylchloroquine concentrations were at ordinarily effective levels (> or = 100 microg/L) on day 8 in both cases of persistent parasitaemia. These findings suggest that clinical resistance to chloroquine by P malariae occurs in the Indonesian archipelago of southeast Asia. |
| spellingShingle | Maguire, J Sumawinata, I Masbar, S Laksana, B Prodjodipuro, P Susanti, I Sismadi, P Mahmud, N Bangs, M Baird, J Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia. |
| title | Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia. |
| title_full | Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia. |
| title_fullStr | Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia. |
| title_full_unstemmed | Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia. |
| title_short | Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia. |
| title_sort | chloroquine resistant plasmodium malariae in south sumatra indonesia |
| work_keys_str_mv | AT maguirej chloroquineresistantplasmodiummalariaeinsouthsumatraindonesia AT sumawinatai chloroquineresistantplasmodiummalariaeinsouthsumatraindonesia AT masbars chloroquineresistantplasmodiummalariaeinsouthsumatraindonesia AT laksanab chloroquineresistantplasmodiummalariaeinsouthsumatraindonesia AT prodjodipurop chloroquineresistantplasmodiummalariaeinsouthsumatraindonesia AT susantii chloroquineresistantplasmodiummalariaeinsouthsumatraindonesia AT sismadip chloroquineresistantplasmodiummalariaeinsouthsumatraindonesia AT mahmudn chloroquineresistantplasmodiummalariaeinsouthsumatraindonesia AT bangsm chloroquineresistantplasmodiummalariaeinsouthsumatraindonesia AT bairdj chloroquineresistantplasmodiummalariaeinsouthsumatraindonesia |