TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival.

TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival.

To better understand the roles of TGF-beta in bone metabolism, we investigated osteoclast survival in response TGF-beta and found that TGF-beta inhibited apoptosis. We examined the receptors involved in promotion of osteoclast survival and found that the canonical TGF-beta receptor complex is involv...

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Bibliographic Details
Main Authors:	Gingery, A, Bradley, E, Pederson, L, Ruan, M, Horwood, N, Oursler, M
Format:	Journal article
Language:	English
Published:	2008

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