Functional motifs in biochemical reaction networks.
The signal-response characteristics of a living cell are determined by complex networks of interacting genes, proteins, and metabolites. Understanding how cells respond to specific challenges, how these responses are contravened in diseased cells, and how to intervene pharmacologically in the decisi...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797081401161416704 |
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| author | Tyson, J Novák, B |
| author_facet | Tyson, J Novák, B |
| author_sort | Tyson, J |
| collection | OXFORD |
| description | The signal-response characteristics of a living cell are determined by complex networks of interacting genes, proteins, and metabolites. Understanding how cells respond to specific challenges, how these responses are contravened in diseased cells, and how to intervene pharmacologically in the decision-making processes of cells requires an accurate theory of the information-processing capabilities of macromolecular regulatory networks. Adopting an engineer's approach to control systems, we ask whether realistic cellular control networks can be decomposed into simple regulatory motifs that carry out specific functions in a cell. We show that such functional motifs exist and review the experimental evidence that they control cellular responses as expected. |
| first_indexed | 2024-03-07T01:13:59Z |
| format | Journal article |
| id | oxford-uuid:8e02f4e6-4f9a-4fbd-854e-566027f4bce0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:13:59Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:8e02f4e6-4f9a-4fbd-854e-566027f4bce02022-03-26T22:54:47ZFunctional motifs in biochemical reaction networks.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8e02f4e6-4f9a-4fbd-854e-566027f4bce0EnglishSymplectic Elements at Oxford2010Tyson, JNovák, BThe signal-response characteristics of a living cell are determined by complex networks of interacting genes, proteins, and metabolites. Understanding how cells respond to specific challenges, how these responses are contravened in diseased cells, and how to intervene pharmacologically in the decision-making processes of cells requires an accurate theory of the information-processing capabilities of macromolecular regulatory networks. Adopting an engineer's approach to control systems, we ask whether realistic cellular control networks can be decomposed into simple regulatory motifs that carry out specific functions in a cell. We show that such functional motifs exist and review the experimental evidence that they control cellular responses as expected. |
| spellingShingle | Tyson, J Novák, B Functional motifs in biochemical reaction networks. |
| title | Functional motifs in biochemical reaction networks. |
| title_full | Functional motifs in biochemical reaction networks. |
| title_fullStr | Functional motifs in biochemical reaction networks. |
| title_full_unstemmed | Functional motifs in biochemical reaction networks. |
| title_short | Functional motifs in biochemical reaction networks. |
| title_sort | functional motifs in biochemical reaction networks |
| work_keys_str_mv | AT tysonj functionalmotifsinbiochemicalreactionnetworks AT novakb functionalmotifsinbiochemicalreactionnetworks |