The bovine viral diarrhoea virus: a model for the study of antiviral molecules interfering with N-glycosylation and folding of envelope glycoprotein
The current treatment of chronic hepatitis C combines interferon alpha and ribavirin andis effective in only half of the patients treated. Considerable efforts are being made to developnovel anti-HVC molecules with a better efficacy particularly for refractory patients. Molecules targeting specifica...
| Principais autores: | , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
Springer Verlag
2015
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| Resumo: | The current treatment of chronic hepatitis C combines interferon alpha and ribavirin andis effective in only half of the patients treated. Considerable efforts are being made to developnovel anti-HVC molecules with a better efficacy particularly for refractory patients. Molecules targeting specifically viral activities are the most studied. However, an antiviral strategy based uniquely on the utilisation of this type of molecules is expected to encounter problems caused by the emergence of viral escape mutants, as already widely described for HIV and HBV. Alternative approaches and molecules are needed to complement antiviral strategies based on inhibitors of viral enzyme. Ideally, new molecules should target steps of the viral cycle that are potentially less likely to give rise to resistance. The assembly and morphogenesis of HCV belong to these yet untargeted steps of the life cycle. |
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