Artefact-free recording of local field potentials with simultaneous stimulation for closed-loop Deep-Brain Stimulation
Continuous high frequency Deep Brain Stimulation (DBS) is a standard therapy for several neurological disorders. Closed-loop DBS is expected to further improve treatment by providing adaptive, on-demand therapy. Local field potentials (LFPs) recorded from the stimulation electrodes are the most ofte...
| Main Authors: | , , , , , , , |
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| Format: | Conference item |
| Language: | English |
| Published: |
Institute of Electrical and Electronics Engineers
2020
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| _version_ | 1797081461279424512 |
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| author | Debarros, J Gaignon, L He, S Pogosyan, A Benjaber, M Denison, T Brown, P Tan, H |
| author_facet | Debarros, J Gaignon, L He, S Pogosyan, A Benjaber, M Denison, T Brown, P Tan, H |
| author_sort | Debarros, J |
| collection | OXFORD |
| description | Continuous high frequency Deep Brain Stimulation (DBS) is a standard therapy for several neurological disorders. Closed-loop DBS is expected to further improve treatment by providing adaptive, on-demand therapy. Local field potentials (LFPs) recorded from the stimulation electrodes are the most often used feedback signal in closed-loop DBS. However, closed-loop DBS based on LFPs requires simultaneous recording and stimulating, which remains a challenge due to persistent stimulation artefacts that distort underlying LFP biomarkers. Here we first investigate the nature of the stimulation-induced artefacts and review several techniques that have been proposed to deal with them. Then we propose a new method to synchronize the sampling clock with the stimulation pulse so that the stimulation artefacts are never sampled, while at the same time the Nyquist-Shannon theorem is satisfied for uninterrupted LFP recording. Test results show that this method achieves true uninterrupted artefact-free LFP recording over a wide frequency band and for a wide range of stimulation frequencies. |
| first_indexed | 2024-03-07T01:14:41Z |
| format | Conference item |
| id | oxford-uuid:8e3f17cc-4f6f-4505-831d-491367a00740 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:14:41Z |
| publishDate | 2020 |
| publisher | Institute of Electrical and Electronics Engineers |
| record_format | dspace |
| spelling | oxford-uuid:8e3f17cc-4f6f-4505-831d-491367a007402022-03-26T22:56:29ZArtefact-free recording of local field potentials with simultaneous stimulation for closed-loop Deep-Brain StimulationConference itemhttp://purl.org/coar/resource_type/c_5794uuid:8e3f17cc-4f6f-4505-831d-491367a00740EnglishSymplectic ElementsInstitute of Electrical and Electronics Engineers2020Debarros, JGaignon, LHe, SPogosyan, ABenjaber, MDenison, TBrown, PTan, HContinuous high frequency Deep Brain Stimulation (DBS) is a standard therapy for several neurological disorders. Closed-loop DBS is expected to further improve treatment by providing adaptive, on-demand therapy. Local field potentials (LFPs) recorded from the stimulation electrodes are the most often used feedback signal in closed-loop DBS. However, closed-loop DBS based on LFPs requires simultaneous recording and stimulating, which remains a challenge due to persistent stimulation artefacts that distort underlying LFP biomarkers. Here we first investigate the nature of the stimulation-induced artefacts and review several techniques that have been proposed to deal with them. Then we propose a new method to synchronize the sampling clock with the stimulation pulse so that the stimulation artefacts are never sampled, while at the same time the Nyquist-Shannon theorem is satisfied for uninterrupted LFP recording. Test results show that this method achieves true uninterrupted artefact-free LFP recording over a wide frequency band and for a wide range of stimulation frequencies. |
| spellingShingle | Debarros, J Gaignon, L He, S Pogosyan, A Benjaber, M Denison, T Brown, P Tan, H Artefact-free recording of local field potentials with simultaneous stimulation for closed-loop Deep-Brain Stimulation |
| title | Artefact-free recording of local field potentials with simultaneous stimulation for closed-loop Deep-Brain Stimulation |
| title_full | Artefact-free recording of local field potentials with simultaneous stimulation for closed-loop Deep-Brain Stimulation |
| title_fullStr | Artefact-free recording of local field potentials with simultaneous stimulation for closed-loop Deep-Brain Stimulation |
| title_full_unstemmed | Artefact-free recording of local field potentials with simultaneous stimulation for closed-loop Deep-Brain Stimulation |
| title_short | Artefact-free recording of local field potentials with simultaneous stimulation for closed-loop Deep-Brain Stimulation |
| title_sort | artefact free recording of local field potentials with simultaneous stimulation for closed loop deep brain stimulation |
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