The effect of diazepam on indices of 5-HT function in man.
The effects of acute and chronic diazepam administration on L-tryptophan induced prolactin release was studied in seven male volunteers. Acute diazepam diminished the prolactin neuroendocrine response to L-tryptophan. On chronic administration this effect was lost, suggesting tolerance had developed...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1986
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| _version_ | 1797081498712539136 |
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| author | Nutt, D Cowen, P Franklin, M Murdock, P Gosden, B Fraser, S |
| author_facet | Nutt, D Cowen, P Franklin, M Murdock, P Gosden, B Fraser, S |
| author_sort | Nutt, D |
| collection | OXFORD |
| description | The effects of acute and chronic diazepam administration on L-tryptophan induced prolactin release was studied in seven male volunteers. Acute diazepam diminished the prolactin neuroendocrine response to L-tryptophan. On chronic administration this effect was lost, suggesting tolerance had developed. The sedative effects of L-tryptophan were unaltered by either acute or chronic diazepam administration. A possible explanation for the tolerance development to the neuroendocrine effects may be the observed reduction in platelet 3H-imipramine binding that was observed. |
| first_indexed | 2024-03-07T01:15:10Z |
| format | Journal article |
| id | oxford-uuid:8e67ba94-0cc9-4c31-814b-994cf3c4e259 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:15:10Z |
| publishDate | 1986 |
| record_format | dspace |
| spelling | oxford-uuid:8e67ba94-0cc9-4c31-814b-994cf3c4e2592022-03-26T22:57:29ZThe effect of diazepam on indices of 5-HT function in man.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8e67ba94-0cc9-4c31-814b-994cf3c4e259EnglishSymplectic Elements at Oxford1986Nutt, DCowen, PFranklin, MMurdock, PGosden, BFraser, SThe effects of acute and chronic diazepam administration on L-tryptophan induced prolactin release was studied in seven male volunteers. Acute diazepam diminished the prolactin neuroendocrine response to L-tryptophan. On chronic administration this effect was lost, suggesting tolerance had developed. The sedative effects of L-tryptophan were unaltered by either acute or chronic diazepam administration. A possible explanation for the tolerance development to the neuroendocrine effects may be the observed reduction in platelet 3H-imipramine binding that was observed. |
| spellingShingle | Nutt, D Cowen, P Franklin, M Murdock, P Gosden, B Fraser, S The effect of diazepam on indices of 5-HT function in man. |
| title | The effect of diazepam on indices of 5-HT function in man. |
| title_full | The effect of diazepam on indices of 5-HT function in man. |
| title_fullStr | The effect of diazepam on indices of 5-HT function in man. |
| title_full_unstemmed | The effect of diazepam on indices of 5-HT function in man. |
| title_short | The effect of diazepam on indices of 5-HT function in man. |
| title_sort | effect of diazepam on indices of 5 ht function in man |
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