Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells.
Hypoxia-inducible factor (HIF) plays an important role in determining patterns of gene expression in cancer. HIF is down-regulated in oxygenated cells by a series of Fe (II) and 2-oxoglutarate dependent dioxygenases that hydroxylate specific residues in the regulatory HIF-alpha subunits. Because the...
প্রধান লেখক: | Knowles, H, Raval, R, Harris, A, Ratcliffe, P |
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বিন্যাস: | Journal article |
ভাষা: | English |
প্রকাশিত: |
2003
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অনুরূপ উপাদানগুলি
অনুরূপ উপাদানগুলি
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Normoxic stabilization of hypoxia-inducible factor-1α by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1
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