Functions of nonclassical MHC and non-MHC-encoded class I molecules.
Fascinating recent discoveries have focused attention on the nonclassical class I molecules. They can exert their function at most levels of the immune response, being part of both innate and adaptive immune systems. They not only have specialized antigen-presentation functions but also play importa...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1999
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| _version_ | 1826284532578385920 |
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| author | Braud, V Allan, D Mcmichael, A |
| author_facet | Braud, V Allan, D Mcmichael, A |
| author_sort | Braud, V |
| collection | OXFORD |
| description | Fascinating recent discoveries have focused attention on the nonclassical class I molecules. They can exert their function at most levels of the immune response, being part of both innate and adaptive immune systems. They not only have specialized antigen-presentation functions but also play important immunoregulatory roles: HLA-E regulates natural killer cells by interacting with CD94/NKG2 receptors; the MIC (MHC class I chain related) glycoproteins appear crucial to the activation of gammadelta T cells in the gastrointestinal epithelium; HLA-G may play a role in controlling the immune response to the fetus; and CD1 molecules are important in defense against bacterial infections, as well as in the development and regulation of a subset of NKT cells expressing a highly restricted TCR repertoire; however not all nonclassical class I molecules have an immunological function, as demonstrated by HFE which is implicated in iron metabolism. |
| first_indexed | 2024-03-07T01:15:15Z |
| format | Journal article |
| id | oxford-uuid:8e6e41ac-4619-45e9-a36f-aa70fe451bc7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:15:15Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:8e6e41ac-4619-45e9-a36f-aa70fe451bc72022-03-26T22:57:48ZFunctions of nonclassical MHC and non-MHC-encoded class I molecules.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8e6e41ac-4619-45e9-a36f-aa70fe451bc7EnglishSymplectic Elements at Oxford1999Braud, VAllan, DMcmichael, AFascinating recent discoveries have focused attention on the nonclassical class I molecules. They can exert their function at most levels of the immune response, being part of both innate and adaptive immune systems. They not only have specialized antigen-presentation functions but also play important immunoregulatory roles: HLA-E regulates natural killer cells by interacting with CD94/NKG2 receptors; the MIC (MHC class I chain related) glycoproteins appear crucial to the activation of gammadelta T cells in the gastrointestinal epithelium; HLA-G may play a role in controlling the immune response to the fetus; and CD1 molecules are important in defense against bacterial infections, as well as in the development and regulation of a subset of NKT cells expressing a highly restricted TCR repertoire; however not all nonclassical class I molecules have an immunological function, as demonstrated by HFE which is implicated in iron metabolism. |
| spellingShingle | Braud, V Allan, D Mcmichael, A Functions of nonclassical MHC and non-MHC-encoded class I molecules. |
| title | Functions of nonclassical MHC and non-MHC-encoded class I molecules. |
| title_full | Functions of nonclassical MHC and non-MHC-encoded class I molecules. |
| title_fullStr | Functions of nonclassical MHC and non-MHC-encoded class I molecules. |
| title_full_unstemmed | Functions of nonclassical MHC and non-MHC-encoded class I molecules. |
| title_short | Functions of nonclassical MHC and non-MHC-encoded class I molecules. |
| title_sort | functions of nonclassical mhc and non mhc encoded class i molecules |
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