MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates
The only currently licensed vaccine against tuberculosis (TB), Bacille Calmette Guérin (BCG), is insufficient to control the epidemic. MTBVAC is a live attenuated strain of Mycobacterium tuberculosis (M.tb) and is one the most advanced TB vaccine candidates in the pipeline. It is more efficacious th...
| প্রধান লেখক: | , , , , , , , , , , , , , , , , |
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| বিন্যাস: | Journal article |
| ভাষা: | English |
| প্রকাশিত: |
Nature Research
2024
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| _version_ | 1826315492309073920 |
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| author | Peralta-Álvarez, MP Downward, K White, A Redondo Azema, H Sibley, L Sarfas, C Morrison, A Dennis, M Diaz-Santana, D Harris, SA Li, S Puentes, E Aguilo, N Martin, C Sharpe, S McShane, H Tanner, R |
| author_facet | Peralta-Álvarez, MP Downward, K White, A Redondo Azema, H Sibley, L Sarfas, C Morrison, A Dennis, M Diaz-Santana, D Harris, SA Li, S Puentes, E Aguilo, N Martin, C Sharpe, S McShane, H Tanner, R |
| author_sort | Peralta-Álvarez, MP |
| collection | OXFORD |
| description | The only currently licensed vaccine against tuberculosis (TB), Bacille Calmette Guérin (BCG), is insufficient to control the epidemic. MTBVAC is a live attenuated strain of Mycobacterium tuberculosis (M.tb) and is one the most advanced TB vaccine candidates in the pipeline. It is more efficacious than BCG in preclinical models including non-human primates (NHPs), and has demonstrated safety and immunogenicity in human populations. To better understand the immune mechanisms underlying the superior efficacy conferred by MTBVAC, we characterized M.tb-specific antibody responses in NHPs vaccinated with either BCG or MTBVAC. MTBVAC vaccination induced higher titers of IgG, IgM and IgA, and higher avidity IgG compared with BCG vaccination. IgG avidity correlated with protection following M.tb challenge in the same animals, validating the association previously reported between this measure and protection in the context of intravenous BCG vaccination, suggesting that IgG avidity may represent a relevant marker or correlate of protection from TB. |
| first_indexed | 2024-12-09T03:26:35Z |
| format | Journal article |
| id | oxford-uuid:8e7de7f2-0257-48b7-a3c7-c0b5cbb8ee09 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:26:35Z |
| publishDate | 2024 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:8e7de7f2-0257-48b7-a3c7-c0b5cbb8ee092024-11-29T20:03:36ZMTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primatesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8e7de7f2-0257-48b7-a3c7-c0b5cbb8ee09EnglishJisc Publications RouterNature Research2024Peralta-Álvarez, MPDownward, KWhite, ARedondo Azema, HSibley, LSarfas, CMorrison, ADennis, MDiaz-Santana, DHarris, SALi, SPuentes, EAguilo, NMartin, CSharpe, SMcShane, HTanner, RThe only currently licensed vaccine against tuberculosis (TB), Bacille Calmette Guérin (BCG), is insufficient to control the epidemic. MTBVAC is a live attenuated strain of Mycobacterium tuberculosis (M.tb) and is one the most advanced TB vaccine candidates in the pipeline. It is more efficacious than BCG in preclinical models including non-human primates (NHPs), and has demonstrated safety and immunogenicity in human populations. To better understand the immune mechanisms underlying the superior efficacy conferred by MTBVAC, we characterized M.tb-specific antibody responses in NHPs vaccinated with either BCG or MTBVAC. MTBVAC vaccination induced higher titers of IgG, IgM and IgA, and higher avidity IgG compared with BCG vaccination. IgG avidity correlated with protection following M.tb challenge in the same animals, validating the association previously reported between this measure and protection in the context of intravenous BCG vaccination, suggesting that IgG avidity may represent a relevant marker or correlate of protection from TB. |
| spellingShingle | Peralta-Álvarez, MP Downward, K White, A Redondo Azema, H Sibley, L Sarfas, C Morrison, A Dennis, M Diaz-Santana, D Harris, SA Li, S Puentes, E Aguilo, N Martin, C Sharpe, S McShane, H Tanner, R MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates |
| title | MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates |
| title_full | MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates |
| title_fullStr | MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates |
| title_full_unstemmed | MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates |
| title_short | MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates |
| title_sort | mtbvac induces superior antibody titers and igg avidity compared to bcg vaccination in non human primates |
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