MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates

MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates

The only currently licensed vaccine against tuberculosis (TB), Bacille Calmette Guérin (BCG), is insufficient to control the epidemic. MTBVAC is a live attenuated strain of Mycobacterium tuberculosis (M.tb) and is one the most advanced TB vaccine candidates in the pipeline. It is more efficacious th...

Podrobná bibliografie
Hlavní autoři:	Peralta-Álvarez, MP, Downward, K, White, A, Redondo Azema, H, Sibley, L, Sarfas, C, Morrison, A, Dennis, M, Diaz-Santana, D, Harris, SA, Li, S, Puentes, E, Aguilo, N, Martin, C, Sharpe, S, McShane, H, Tanner, R
Médium:	Journal article
Jazyk:	English
Vydáno:	Nature Research 2024

Podobné jednotky

MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates
Autor: Marco Polo Peralta-Álvarez, a další
Vydáno: (2024-11-01)

Low-dose M.tb infection but not BCG or MTBVAC vaccination enhances heterologous antibody titres in non-human primates
Autor: Marco Polo Peralta Alvarez, a další
Vydáno: (2024-05-01)

Low-dose M.tb infection but not BCG or MTBVAC vaccination enhances heterologous antibody titres in non-human primates
Autor: Alvarez, MPP, a další
Vydáno: (2024)

Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis
Autor: Alvaro Roy, a další
Vydáno: (2019-10-01)

Development of a non-human primate BCG infection model for the evaluation of candidate tuberculosis vaccines
Autor: Harris, S, a další
Vydáno: (2017)

MTBVAC from discovery to clinical trials in tuberculosis-endemic countries
Autor: Dessislava Marinova, a další
Vydáno: (2017-06-01)

Induction of functional specific antibodies, IgG-secreting plasmablasts and memory B cells following BCG vaccination
Autor: Bitencourt, J, a další
Vydáno: (2021)

MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies
Autor: Andrew D. White, a další
Vydáno: (2021-01-01)

Salivary anti-PGL IgM and IgA titers and serum antibody IgG titers and avidities in leprosy patients and their correlation with time of infection and antigen exposure
Autor: Aparecida T. Nagao-Dias, a další

MTBVAC: Attenuating the Human Pathogen of Tuberculosis (TB) Toward a Promising Vaccine against the TB Epidemic
Autor: Jesus Gonzalo-Asensio, a další
Vydáno: (2017-12-01)

The humoral immune response to BCG vaccination
Autor: Tanner, R, a další
Vydáno: (2019)

Immune cell population dynamics following neonatal BCG vaccination and aerosol BCG revaccination in rhesus macaques
Autor: Laura Sibley, a další
Vydáno: (2024-07-01)

Revaccination with BCG: does it work?
Autor: McShane, H
Vydáno: (2024)

Understanding BCG is the key to improving it.
Autor: McShane, H
Vydáno: (2013)

Predicting IFN-γ responses after BCG vaccination in humans from macaques: A proof-of-concept study of Immunostimulation/Immunodynamic modelling methods
Autor: Rhodes, S, a další
Vydáno: (2017)

Construction and characterization of recombinant MTBVAC. HIV, a new live attenuated vaccine against HIV and tuberculosis
Autor: Saubi, N, a další
Vydáno: (2018)

Serological IgG avidity test for ocular toxoplasmosis
Autor: Suresh S, a další
Vydáno: (2012-01-01)

Induction of Functional Specific Antibodies, IgG-Secreting Plasmablasts and Memory B Cells Following BCG Vaccination
Autor: Julia Bitencourt, a další
Vydáno: (2022-01-01)

Editorial commentary: Understanding BCG is the key to improving it
Autor: McShane, H
Vydáno: (2014)

Development of a primate model for tuberculosis vaccine research: IFN-gamma responses induced by BCG vaccination and M-tuberculosis infection in macaques
Autor: Dowall, S, a další
Vydáno: (2007)

Role of IgG avidity in eyes with active Toxoplasma retinochoroiditis
Autor: Pratik Lakhmawar, a další
Vydáno: (2024-02-01)

IgG Avidity Test in Congenital Toxoplasmosis Diagnoses in Newborns
Autor: Zulmirene Cardoso Fonseca, a další
Vydáno: (2017-06-01)

Diagnosis of Toxoplasmosis in Pregnant Women by IgG Avidity Assay
Autor: M. Roozbehani, a další
Vydáno: (2015-02-01)

Nanoscale spatial dependence of avidity in an IgG1 antibody
Autor: Agnieszka Jendroszek, a další
Vydáno: (2021-06-01)

IV BCG Vaccination and Aerosol BCG Revaccination Induce Mycobacteria-Responsive γδ T Cells Associated with Protective Efficacy against <i>M. tb</i> Challenge
Autor: Alexandra L. Morrison, a další
Vydáno: (2023-10-01)

MTBVAC-based TB-HIV vaccine is safe, elicits HIV-T cell responses, and protects against Mycobacterium tuberculosis in Mice
Autor: Broset, E, a další
Vydáno: (2019)

MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice
Autor: Esther Broset, a další
Vydáno: (2019-06-01)

Longitudinal antibody titer, avidity, and neutralizing responses after SARS-CoV-2 infection
Autor: Jonathon M. Monroe, a další
Vydáno: (2022-11-01)

EPSTEIN-BARR VIRUS INFECTIONS – AVIDITY TEST FOR IgG ANTIBODIES
Autor: Katja Strašek, a další
Vydáno: (2001-06-01)

Diagnosis of Acute Toxoplasmosis in the First Trimester of Pregnancy by IgG Avidity
Autor: Afshin Azimi, a další
Vydáno: (2022-06-01)

Measurement of the IgG Avidity Index in the Diagnosis of Clinical Toxocariasis Patients
Autor: Estelle Menu, a další
Vydáno: (2021-08-01)

New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia.
Autor: Raquel Tarancón, a další
Vydáno: (2020-04-01)

The Humoral Immune Response to BCG Vaccination
Autor: Rachel Tanner, a další
Vydáno: (2019-06-01)

Indeterminate/moderate IgG avidity during HCMV infection: comparison of methods
Autor: Massimo De Paschale, a další
Vydáno: (2010-03-01)

A non-human primate in vitro functional assay for the early evaluation of TB vaccine candidates
Autor: Tanner, R, a další
Vydáno: (2021)

Characterization of the Infant Immune System and the Influence and Immunogenicity of BCG Vaccination in Infant and Adult Rhesus Macaques
Autor: Charlotte Sarfas, a další
Vydáno: (2021-10-01)

Evaluation of a human BCG challenge model to assess antimycobacterial immunity induced by BCG and a candidate TB vaccine, MVA85A, alone and in combination
Autor: Harris, S, a další
Vydáno: (2013)

Standardization and uses of IgG antibodies avidity assays in the laboratorial diagnosis of animal toxoplasmosis
Autor: Luciana Regina Meireles
Vydáno: (2005-08-01)

Seropositivity of Cytomegalovirus, Rubella and Toxoplasma Gondii in Pregnant Women and IgG Avidity Tests
Autor: Cemal ÇİÇEK, a další
Vydáno: (2023-04-01)

Detection of persistent low IgG avidity–an interpretative problem in the diagnosis of acute toxoplasmosis
Autor: Petr Kodym, a další
Vydáno: (2023-01-01)