Plasma membrane rafts engaged in T cell signalling: new developments in an old concept.
Considerable controversy arose over the concept that cholesterol/sphingolipid-rich rafts in the T cell plasma membrane serve as a platform for TCR signalling reactions. This controversy was founded on the initial definition of rafts as detergent resistant membranes which later turned out to misrepr...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1826284545722286080 |
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| author | Harder, T Sangani, D |
| author_facet | Harder, T Sangani, D |
| author_sort | Harder, T |
| collection | OXFORD |
| description | Considerable controversy arose over the concept that cholesterol/sphingolipid-rich rafts in the T cell plasma membrane serve as a platform for TCR signalling reactions. This controversy was founded on the initial definition of rafts as detergent resistant membranes which later turned out to misrepresent many features of cell membrane organisation under physiological conditions. Raft-organisation was subsequently studied using a number of detergent-free experimental approaches. The results led to a refined perception of membrane rafts which resolves the controversies. Here we review new biophysical and biochemical data which provide an updated picture of the highly dynamic nanometer-sized cholesterol/sphingolipid-rich raft domains stabilised by protein-networks to form TCR signalling platforms in the T cell plasma membrane. |
| first_indexed | 2024-03-07T01:15:27Z |
| format | Journal article |
| id | oxford-uuid:8e7f4607-0901-4cb4-9a50-79a4bcefd07f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:15:27Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:8e7f4607-0901-4cb4-9a50-79a4bcefd07f2022-03-26T22:58:07ZPlasma membrane rafts engaged in T cell signalling: new developments in an old concept.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8e7f4607-0901-4cb4-9a50-79a4bcefd07fEnglishSymplectic Elements at Oxford2009Harder, TSangani, D Considerable controversy arose over the concept that cholesterol/sphingolipid-rich rafts in the T cell plasma membrane serve as a platform for TCR signalling reactions. This controversy was founded on the initial definition of rafts as detergent resistant membranes which later turned out to misrepresent many features of cell membrane organisation under physiological conditions. Raft-organisation was subsequently studied using a number of detergent-free experimental approaches. The results led to a refined perception of membrane rafts which resolves the controversies. Here we review new biophysical and biochemical data which provide an updated picture of the highly dynamic nanometer-sized cholesterol/sphingolipid-rich raft domains stabilised by protein-networks to form TCR signalling platforms in the T cell plasma membrane. |
| spellingShingle | Harder, T Sangani, D Plasma membrane rafts engaged in T cell signalling: new developments in an old concept. |
| title | Plasma membrane rafts engaged in T cell signalling: new developments in an old concept. |
| title_full | Plasma membrane rafts engaged in T cell signalling: new developments in an old concept. |
| title_fullStr | Plasma membrane rafts engaged in T cell signalling: new developments in an old concept. |
| title_full_unstemmed | Plasma membrane rafts engaged in T cell signalling: new developments in an old concept. |
| title_short | Plasma membrane rafts engaged in T cell signalling: new developments in an old concept. |
| title_sort | plasma membrane rafts engaged in t cell signalling new developments in an old concept |
| work_keys_str_mv | AT hardert plasmamembraneraftsengagedintcellsignallingnewdevelopmentsinanoldconcept AT sanganid plasmamembraneraftsengagedintcellsignallingnewdevelopmentsinanoldconcept |