Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase pin1

Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase pin1

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Ring-shaped cohesin keeps sister chromatids paired until cleavage of its Scc1/Rad21 subunit by separase triggers chromosome segregation in anaphase. Vertebrate separase is held inactive by mutually exclusive binding to securin or Cdk1-cyclin B1 and becomes unleashed only upon ubiquitin-dependent deg...

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Bibliographic Details
Main Authors:	Hellmuth, S, Rata, S, Brown, A, Heidmann, S, Novak, B, Stemmann, O
Format:	Journal article
Language:	English
Published:	Elsevier 2015

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