Acyclic quaternary centers from asymmetric conjugate addition of alkylzirconium reagents to linear trisubstituted enones
Synthetic methods for the selective formation of all carbon quaternary centres in non-cyclic systems are rare. Here we report highly enantioselective Cu-catalytic asymmetric conjugate addition of alkylzirconium species to twelve different acyclic trisubstituted enones. A variety of sp(3)-hybridized...
| Главные авторы: | , |
|---|---|
| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
Royal Society of Chemistry
2016
|